Publication Name	World Journal of Hepatology
Manuscript ID	95662
Country	China

Received	2024-04-15 17:07
Peer-Review Started	2024-04-15 17:07
To Make the First Decision
Return for Revision	2024-05-11 08:26
Revised	2024-05-23 18:26
Second Decision	2024-06-11 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-11 08:28
Articles in Press	2024-06-11 08:28
Publication Fee Transferred	2024-06-12 05:45
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-16 00:48
Publish the Manuscript Online	2024-07-26 10:33

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Li Mei, Shu-Yi Wu, Si-Lan Wu, Xiao-Lin Luo, Si-Xing Huang, Rui Liu and Zhe Qiang
ORCID	Author(s) ORCID Number Zhe Qiang http://orcid.org/0000-0002-3673-5258
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Fundamental Research Funds jbky20210001 Key Programs of Technological Innovation and Application Development of Chongqing cstc2021jscx-dxwtBX0016 Natural Science Foundation of Chongqing cstc2021jcyj-msxmX0793 Chongqing Performance Incentive-oriented Project jxjl20220007 Science and Technology Project in Social Livelihood of Bishan District, Chongqing, China BSKJ0078 and BSKJ0075
Corresponding Author	Zhe Qiang, MD, Associate Professor, Department of Pharmacology and Toxicology, Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation Laboratory, Chongqing Academy of Chinese Materia Medica, No. 34 Nanshan Road, Huangjueya, Nan'an District, Chonqing 400061, China. qiangzhe@cqctcm.edu.cn
Key Words	Hepatic steatosis; Inflammation; Sex hormone metabolism; Male hormone; Phosphatase and tensin homolog deleted on chromosome ten
Core Tip	In this study, the modified Xiaoyao San (MXS) formula was found can alleviated inflammation and hepatic steatosis in nonalcoholic steatohepatitis (NASH) by suppressing male hormone metabolism and modulating inflammation/lipid metabolism-related signaling and factors. It suggested that the regulation of sex hormone metabolism and associated signaling could be new avenues for mechanistic research on NASH and for early diagnosis and treatment. This study offers substantial evidence for the therapeutic potential of MXS in NASH and makes a valuable contribution to the development of new drugs for this condition.
Publish Date	2024-07-26 10:33
Citation	<p>Mei XL, Wu SY, Wu SL, Luo XL, Huang SX, Liu R, Qiang Z. Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism. <i>World J Hepatol</i> 2024; 16(7): 1051-1066</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i7/1051.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i7.1051

Full Article (PDF)	WJH-16-1051-with-cover.pdf
The ARRIVE Guidelines	95662-The-ARRIVE-Guidelines.pdf
Manuscript File	95662_Auto_Edited-YJP.docx
Answering Reviewers	95662-answering-reviewers.pdf
Audio Core Tip	95662-audio.mp3
Biostatistics Review Certificate	95662-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95662-conflict-of-interest-statement.pdf
Copyright License Agreement	95662-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95662-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	95662-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	95662-non-native-speakers.pdf
Supplementary Material	95662-supplementary-material.pdf
Peer-review Report	95662-peer-reviews.pdf
Scientific Misconduct Check	95662-scientific-misconduct-check.jpg
Scientific Editor Work List	95662-scientific-editor-work-list.pdf
CrossCheck Report	95662-crosscheck-report.pdf