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Articles Published Processes
11/12/2024 12:23:35 PM | Browse: 246 | Download: 915
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Received |
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2024-04-16 09:36 |
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Peer-Review Started |
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2024-04-16 09:36 |
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First Decision by Editorial Office Director |
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2024-08-17 19:47 |
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Return for Revision |
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2024-08-17 19:47 |
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Revised |
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2024-09-09 16:17 |
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Publication Fee Transferred |
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2024-10-11 03:17 |
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Second Decision by Editor |
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2024-10-08 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-08 07:45 |
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Articles in Press |
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2024-10-08 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-10-21 07:23 |
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Publish the Manuscript Online |
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2024-11-12 12:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Vitamin D 1,25-Dihydroxyvitamin D₃ reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Jing Luo, Xian-Wen Dong, Hua Ye, Qiao-Su Zhao, Qiu-Bo Zhang, Wen-Ying Guo, Hui-Wei Liu and Feng Xu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Feng Xu, MAMS, Chief Physician, Department of Gastroenterology, Ningbo Medical Center Lihuili Hospital, No. 57 Xingning Road, Ningbo 315000, Zhejiang Province, China. xufeng200468@126.com |
| Key Words |
Non-alcoholic fatty liver disease; Hepatocytes; Macrophages; Polarization; Vitamin D receptor; Peroxisome proliferator activated receptor γ |
| Core Tip |
Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty liver disease, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the vitamin D receptor-peroxisome proliferator activated receptor γ pathway. The involvement of 1,25(OH)2D3 in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes. |
| Publish Date |
2024-11-12 12:23 |
| Citation |
Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, Guo WY, Liu HW, Xu F. Vitamin D 1,25-Dihydroxyvitamin D₃ reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. World J Gastrointest Oncol 2024; 16(12): 4685-4699 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i12/4685.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i12.4685 |
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