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Articles Published Processes
9/11/2014 10:02:00 AM | Browse: 1221 | Download: 1473
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Received |
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2014-02-18 10:10 |
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Peer-Review Started |
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2014-02-18 14:32 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-03-27 09:19 |
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Revised |
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2014-04-02 21:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-06-27 17:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-06-27 17:52 |
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Articles in Press |
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2014-06-27 18:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-29 15:17 |
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Publish the Manuscript Online |
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2014-09-11 10:03 |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Autobiography |
| Article Title |
Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Amie J Dirks-Naylor, Samir A Kouzi, Joseph D Bero, Ngan TK Tran, Sendra Yang and Raean Mabolo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Amie J. Dirks-Naylor, Ph.D.
Associate Professor
School of Pharmacy
Wingate University
515 N. Main Street
Wingate, NC 28174
Tel: (704) 233-8341
Fax: (704) 233-8332
anaylor@wingate.edu |
| Key Words |
sirtuin; caspase; apoptosis; acetylation; HDAC |
| Core Tip |
The study revealed five interesting findings that open the door for new areas of investigation: 1.) Dox induces proteome lysine deacetylation, 2.) Lysine deacetylation is, at least in part, due to a decrease in HAT activity, 3.) Lysine deacetylation is likely not associated with an apoptotic environment, and 4.) Dox-induced hepatic injury is associated with caspase-12 activation, and 5.) Caspase-12 activation is not involved in apoptosis induction. These results may in the future translate to lysine acetylation homeostasis and/or caspase-12 as therapeutic targets. |
| Publish Date |
2014-09-11 10:03 |
| Citation |
Dirks-Naylor AJ, Kouzi SA, Bero JD, Tran NTK, Yang S, Mabolo R. Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment. World J Biol Chem 2014; 5(3): 377-386 |
| URL |
http://www.wjgnet.com/1949-8454/full/v5/i3/377.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v5.i3.377 |
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