Publication Name	World Journal of Biological Chemistry
Manuscript ID	9570
Country	United States

Received	2014-02-18 10:10
Peer-Review Started	2014-02-18 14:32
To Make the First Decision	2014-03-26 15:17
Return for Revision	2014-03-27 09:19
Revised	2014-04-02 21:47
Second Decision	2014-06-27 17:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-27 17:52
Articles in Press	2014-06-27 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-29 15:17
Publish the Manuscript Online	2014-09-11 10:03

ISSN	1949-8454 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment
Manuscript Source	Unsolicited Manuscript
All Author List	Amie J Dirks-Naylor, Samir A Kouzi, Joseph D Bero, Ngan TK Tran, Sendra Yang and Raean Mabolo
Funding Agency and Grant Number
Corresponding Author	Amie J. Dirks-Naylor, Ph.D. Associate Professor School of Pharmacy Wingate University 515 N. Main Street Wingate, NC 28174 Tel: (704) 233-8341 Fax: (704) 233-8332 anaylor@wingate.edu
Key Words	sirtuin; caspase; apoptosis; acetylation; HDAC
Core Tip	The study revealed five interesting findings that open the door for new areas of investigation: 1.) Dox induces proteome lysine deacetylation, 2.) Lysine deacetylation is, at least in part, due to a decrease in HAT activity, 3.) Lysine deacetylation is likely not associated with an apoptotic environment, and 4.) Dox-induced hepatic injury is associated with caspase-12 activation, and 5.) Caspase-12 activation is not involved in apoptosis induction. These results may in the future translate to lysine acetylation homeostasis and/or caspase-12 as therapeutic targets.
Publish Date	2014-09-11 10:03
Citation	Dirks-Naylor AJ, Kouzi SA, Bero JD, Tran NTK, Yang S, Mabolo R. Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment. World J Biol Chem 2014; 5(3): 377-386
URL	http://www.wjgnet.com/1949-8454/full/v5/i3/377.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i3.377

Full Article (PDF)	WJBC-5-377.pdf
Full Article (Word)	WJBC-5-377.doc
Manuscript File	9570-Review.doc
Answering Reviewers	9570-Answering reviewers.pdf
Copyright License Agreement	9570-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140218024536.pdf
Peer-review Report	9570-Peer review(s).pdf
Scientific Misconduct Check	9570-CrossCheck.jpg
Scientific Editor Work List	9570-Scientific editor work list.pdf