| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Transcriptome analysis suggests broad jejunal alterations in Linghu’s obesity-diarrhea syndrome: A pilot study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Tong Niu, Xiang-Yao Wang, Yan Wang, Ke Han, Nan Ru, Jing-Yuan Xiang and En-Qiang Linghu |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
En-Qiang Linghu, MD, PhD, Chief Physician, Director, Director, Professor, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com |
| Key Words |
Obesity; Chronic diarrhea; Jejunum; Transcriptome; Intestinal barrier |
| Core Tip |
This study analyzed the transcriptomic characteristics of the jejunal mucosa in patients with Linghu’s obesity-diarrhea syndrome (ODS). The jejunal gene expression profile of obese people without diarrhea was similar to that of healthy controls. However, the jejunal gene expression profile of ODS patients showed significant changes, characterized by the up-regulation of nutrient absorption, digestion, and transport and the down-regulation of rRNA processing, mitochondrial translation, antimicrobial humoral response, DNA replication, and DNA repair. In addition, although intestinal barrier damage was present in all obese individuals, it appeared to be more severe in ODS patients. |
| Publish Date |
2024-06-03 08:49 |
| Citation |
<p>Niu XT, Wang XY, Wang Y, Han K, Ru N, Xiang JY, Linghu EQ. Transcriptome analysis suggests broad jejunal alterations in Linghu’s obesity-diarrhea syndrome: A pilot study. <i>World J Gastroenterol</i> 2024; 30(21): 2777-2792</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i21/2777.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i21.2777 |
