7/12/2024 3:55:59 PM | Browse: 115 | Download: 215
| Publication Name | World Journal of Gastrointestinal Oncology |
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| Manuscript ID | 95854 |
| Country | Japan |
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| ISSN | 1948-5204 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Oncology | ||||||||||||||||||||||||||||
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| Manuscript Type | Case Report | ||||||||||||||||||||||||||||
| Article Title | BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report | ||||||||||||||||||||||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||||||||||||||||||||||
| All Author List | Makiko Sasaki, Takaya Shimura, Hirotada Nishie, Keita Kuroyanagi, Takuya Kanno, Shigeki Fukusada, Naomi Sugimura, Yusuke Mizuno, Takayuki Nukui, Konomu Uno, Yuki Kojima, Ruriko Nishigaki, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota and Hiromi Kataoka | ||||||||||||||||||||||||||||
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| Corresponding Author | Takaya Shimura, MD, PhD, Associate Professor, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan. tshimura@med.nagoya-cu.ac.jp | ||||||||||||||||||||||||||||
| Key Words | v-raf murine sarcoma viral oncogene homolog B K601E-mutation; Metastatic colorectal cancer; Encorafenib; Binimetinib; Cetuximab; Case report | ||||||||||||||||||||||||||||
| Core Tip | With the development and standardization of next-generation sequencing, it is anticipated that there will be an increased to discover previously unidentified genetic mutations. BRAF non-V600 mutations including K601E-mutation are rare mutation and the clinical behavior has not been understood. In this case, a comprehensive genomic profiling panel revealed a BRAF K601E mutation, which was not covered in the initial companion diagnostics. A combination of encorafenib, binimetinib, and cetuximab had great effect. It is important to consider the possibility of discovering rare mutations, which could expand treatment options. | ||||||||||||||||||||||||||||
| Publish Date | 2024-07-12 15:55 | ||||||||||||||||||||||||||||
| Citation | Sasaki M, Shimura T, Nishie H, Kuroyanagi K, Kanno T, Fukusada S, Sugimura N, Mizuno Y, Nukui T, Uno K, Kojima Y, Nishigaki R, Tanaka M, Ozeki K, Kubota E, Kataoka H. BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report. World J Gastrointest Oncol 2024; 16(7): 3357-3363 |
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| URL | https://www.wjgnet.com/1948-5204/full/v16/i7/3357.htm | ||||||||||||||||||||||||||||
| DOI | https://dx.doi.org/10.4251/wjgo.v16.i7.3357 |
| Full Article (PDF) | WJGO-16-3357-with-cover.pdf |
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| CARE Checklist–2016 | 95854-CARE-Checklist-2016.pdf |
| Manuscript File | 95854-Review-Filipodia.docx |
| Answering Reviewers | 95854-answering-reviewers.pdf |
| Audio Core Tip | 95854-audio.mp3 |
| Conflict-of-Interest Disclosure Form | 95854-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 95854-copyright-assignment.pdf |
| Signed Consent for Treatment Form(s) or Document(s) | 95854-informed-consent-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 95854-non-native-speakers.pdf |
| Peer-review Report | 95854-peer-reviews.pdf |
| Scientific Misconduct Check | 95854-scientific-misconduct-check.jpg |
| Scientific Editor Work List | 95854-scientific-editor-work-list.pdf |
| CrossCheck Report | 95854-crosscheck-report.pdf |