Publication Name	World Journal of Hepatology
Manuscript ID	95909
Country	China

Received	2024-04-22 02:06
Peer-Review Started	2024-04-22 02:06
To Make the First Decision
Return for Revision	2024-05-18 14:30
Revised	2024-05-26 13:12
Second Decision	2024-06-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-14 07:52
Articles in Press	2024-06-14 07:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-10 06:40
Publish the Manuscript Online	2024-07-26 10:33

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Acute liver failure: A clinically severe syndrome characterized by intricate mechanisms
Manuscript Source	Unsolicited Manuscript
All Author List	Ran An and Jing-Lin Wang
ORCID	Author(s) ORCID Number Jing-Lin Wang http://orcid.org/0000-0002-4349-750X
Funding Agency and Grant Number
Corresponding Author	Jing-Lin Wang, Doctor, Associate Professor, Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. cw20120817@163.com
Key Words	Acute liver failure; Hepatocyte; Macrophage; Necroptosis; Pyroptosis; Ferroptosis
Core Tip	Acute Liver Failure (ALF) is a clinical syndrome characterized by a complex pathogenesis and a high mortality rate. The core mechanism that triggers ALF has been shown to be the imbalance of the immune microenvironment. The functions of the immune system during liver injury are diverse, encompassing both the early clearance of damaging substances and later tissue repair. However, achieving a smooth transition between these functions and avoiding the aggravation of liver injury caused by excessive activation or suppression of the immune system is a current research hotspot.
Publish Date	2024-07-26 10:33
Citation	<p>An R, Wang JL. Acute liver failure: A clinically severe syndrome characterized by intricate mechanisms. <i>World J Hepatol</i> 2024; 16(7): 1067-1069</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i7/1067.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i7.1067

Full Article (PDF)	WJH-16-1067-with-cover.pdf
Manuscript File	95909_Auto_Edited-YJP.docx
Answering Reviewers	95909-answering-reviewers.pdf
Audio Core Tip	95909-audio.m4a
Conflict-of-Interest Disclosure Form	95909-conflict-of-interest-statement.pdf
Copyright License Agreement	95909-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	95909-non-native-speakers.pdf
Peer-review Report	95909-peer-reviews.pdf
Scientific Misconduct Check	95909-scientific-misconduct-check.png
Scientific Editor Work List	95909-scientific-editor-work-list.pdf
CrossCheck Report	95909-crosscheck-report.png
CrossCheck Report	95909-crosscheck-report.pdf