Publication Name	World Journal of Hematology
Manuscript ID	9592
Country	Japan

Received	2014-02-19 12:08
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision	2014-02-20 20:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 20:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-18 04:31
Typeset the Manuscript	2014-11-04 16:47
Publish the Manuscript Online	2014-11-14 13:04

ISSN	2218-6204 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Granulysin and its clinical significance as a biomarker of immune response and NK cell related neoplasms
Manuscript Source	Invited Manuscript
All Author List	Masayuki Nagasawa, Kazuyuki Ogawa, Kinya Nagata and Norio Shimizu
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research from Ministry of Education Science and Culture Japan 24591541 (to Nagasawa M)
Corresponding Author	Masayuki Nagasawa, MD, PhD, Department of Hematology, Oncology, and Immunology, Tokyo Bay Urayasu/Ichikawa Medical Center, 3-4-32, Todaijima, Urayasu-city, Chiba 279-0001, Japan. mnagasawa.ped@tmd.ac.jp
Key Words	Granulysin; Saposin-like protein family; Natural killer cell; Cytotoxic T lymphocyte
Core Tip	Granulysin is a cytotoxic granular protein expressed in cytotoxic T cells, natural killer (NK) cells and γδT cells, and has anti-microbial activity against microorganisms such as bacteria, fungi, mycobacteria and parasites, as well as tumoricidal activity against some tumors. It is secreted constitutively and in a trigger-dependent manner. Clinically, serum granulysin is a unique biomarker for immune response, immune capacity and NK cell related neoplasms.
Publish Date	2014-11-14 13:04
Citation	Nagasawa M, Ogawa K, Nagata K, Shimizu N. Granulysin and its clinical significance as a biomarker of immune response and NK cell related neoplasms. World J Hematol 2014; 3(4): 128-137
URL	http://www.wjgnet.com/2218-6204/full/v3/i4/128.htm
DOI	http://dx.doi.org/10.5315/wjh.v3.i4.128

Full Article (PDF)	WJH-3-128.pdf
Full Article (Word)	WJH-3-128.doc
Manuscript File	9592-Review.doc
Answering Reviewers	9592-Answering reviewers.pdf
Copyright License Agreement	9592-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9592-Language certificate.pdf
Peer-review Report	9592-Peer review(s).pdf
Scientific Editor Work List	9592-Scientific editor work list.doc