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Publication Name World Journal of Hematology
Manuscript ID 9592
Country of Manuscript Source Japan
Received
2014-02-19 12:08
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision
2014-02-20 20:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-20 20:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-03-18 04:31
Typeset the Manuscript
2014-11-04 16:47
Publish the Manuscript Online
2014-11-14 13:04
ISSN 2218-6204 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Granulysin and its clinical significance as a biomarker of immune response and NK cell related neoplasms
Manuscript Source Invited Manuscript
All Author List Masayuki Nagasawa, Kazuyuki Ogawa, Kinya Nagata and Norio Shimizu
Funding Agency and Grant Number
Funding Agency Grant Number
Grant-in-Aid for Scientific Research from Ministry of Education
Science and Culture Japan 24591541 (to Nagasawa M)
Corresponding author Masayuki Nagasawa, MD, PhD, Department of Hematology, Oncology, and Immunology, Tokyo Bay Urayasu/Ichikawa Medical Center, 3-4-32, Todaijima, Urayasu-city, Chiba 279-0001, Japan. mnagasawa.ped@tmd.ac.jp
Keywords Granulysin; Saposin-like protein family; Natural killer cell; Cytotoxic T lymphocyte
Core Tip Granulysin is a cytotoxic granular protein expressed in cytotoxic T cells, natural killer (NK) cells and γδT cells, and has anti-microbial activity against microorganisms such as bacteria, fungi, mycobacteria and parasites, as well as tumoricidal activity against some tumors. It is secreted constitutively and in a trigger-dependent manner. Clinically, serum granulysin is a unique biomarker for immune response, immune capacity and NK cell related neoplasms.
Publish Date 2014-11-14 13:04
Citation Nagasawa M, Ogawa K, Nagata K, Shimizu N. Granulysin and its clinical significance as a biomarker of immune response and NK cell related neoplasms. World J Hematol 2014; 3(4): 128-137
Url http://www.wjgnet.com/2218-6204/full/v3/i4/128.htm
DOI http://dx.doi.org/10.5315/wjh.v3.i4.128
Full Article (PDF) WJH-3-128.pdf
Full Article (Word) WJH-3-128.doc
Manuscript File 9592-Review.doc
Answering Reviewers 9592-Answering reviewers.pdf
Copyright License Agreement 9592-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9592-Language certificate.pdf
Peer-review Report 9592-Peer review(s).pdf
Scientific Editor Work List 9592-Scientific editor work list.doc