| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Lei Wang, Bing-Wei Yang, Xin-Yan Wang, Xue Chen, Wei-Dong Li, Hao-Yu Zhai, Ying Wu, Mu-Yao Cui, Jia-He Wu, Qing-Hui Meng and Nan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82174464 |
| China Academy of Traditional Chinese Medicine Science and Technology Innovation Project |
No. CI2021A01806 |
| Central High Level Traditional Chinese Medicine Hospital Clinical Research and Achievement Transformation Ability Enhancement Project |
No. HLCMHPP2023085 |
|
| Corresponding Author |
Wei-Dong Li, MD, Chief Doctor, Department of Scientific Research Management, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beijiange, Xicheng District, Beijing 100053, China. liweidongdoctor@hotmail.com |
| Key Words |
Colorectal cancer; Baijiangcao (Herba Patriniae); Yiyiren (Coix seed); Acacetin; Proliferation; Migration; Apoptosis; Network pharmacology |
| Core Tip |
We identified acacetin as the key active ingredient of “Herba Patriniae and Coix seed.” Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses suggested that “Herba Patriniae and Coix seed” acts on colorectal cancer (CRC) through the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, and molecular docking showed that the best docking effect was between acacetin and AKT1. In vitro experiment results corroborated that acacetin inhibits the proliferation and migration, and promotes apoptosis of CRC cells through the PI3K/Akt/p53 signaling pathway. |
| Publish Date |
2024-08-08 04:58 |
| Citation |
Wang CL, Yang BW, Wang XY, Chen X, Li WD, Zhai HY, Wu Y, Cui MY, Wu JH, Meng QH, Zhang N. Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation. World J Gastrointest Oncol 2024; 16(8): 3539-3558 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i8/3539.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i8.3539 |
