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12/2/2014 10:47:00 AM | Browse: 926 | Download: 963
Publication Name World Journal of Gastroenterology
Manuscript ID 9597
Country/Territory Taiwan
Received
2014-02-20 12:36
Peer-Review Started
2014-02-20 15:50
To Make the First Decision
2014-03-13 18:57
Return for Revision
2014-03-20 08:20
Revised
2014-04-10 08:41
Second Decision
2014-06-23 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-23 10:18
Articles in Press
2014-06-23 10:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-20 11:51
Publish the Manuscript Online
2014-12-02 10:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Autobiography
Article Title Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53
Manuscript Source Unsolicited Manuscript
All Author List Hsi-Hsien Hsu, Wei-Wen Kuo, Da-Tong Ju, Yu-Lan Yeh, Chuan-Chou Tu, Ying-Lan Tsai, Chia-Yao Shen, Sheng-Huang Chang, Li-Chin Chung and Chih-Yang Huang
Funding Agency and Grant Number
Funding Agency Grant Number
Taiwan Department of Health Clinical Trial and Research Center of Excellence MOHW103-TDU-B-212-11300
Corresponding Author Chih-Yang Huang, PhD, Graduate Institute of Basic Medical Science, China Medical University, No. 91 Hsueh-Shih Road, Taichung 404, Taiwan. cyhuang@mail.cmu.edu.tw
Key Words Estrogen; Estrogen agonist; Estrogen receptors; Human colon cancer cell; p53
Core Tip The present study is to investigate the effects of 17?-estradiol via estrogen receptors or directly administration of ERs agonist on the development of human colorectal cancer, and to elucidate whether the effect was regulated by tumor suppressor gene p53. Here, our results showed that 17?-estradiol and/or ERs agonist treatment in human LoVo colorectal cancer cells could active p53, then up-regulated p21 and p27 protein levels, subsequently inhibited downstream target gene, cyclin D1, which regulated the cell proliferation.
Publish Date 2014-12-02 10:46
Citation Hsu HH, Kuo WW, Ju DT, Yeh YL, Tu CC, Tsai YL, Shen CY, Chang SH, Chung CL, Huang CY. Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53. World J Gastroenterol 2014; 20(44): 16665-16673
URL http://www.wjgnet.com/1007-9327/full/v20/i44/16665.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i44.16665
Full Article (PDF) WJG-20-16665.pdf
Full Article (Word) WJG-20-16665.doc
Manuscript File 9597-Review.doc
Answering Reviewers 9597-Answering reviewers.pdf
Copyright License Agreement 9597-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9597-Language certificate.pdf
Peer-review Report 9597-Peer review.pdf
Scientific Misconduct Check 9597-CrossCheck.jpg
Scientific Editor Work List 9597-Scientific editor work list.pdf