Publication Name	World Journal of Gastroenterology
Manuscript ID	9597
Country	Taiwan

Received	2014-02-20 12:36
Peer-Review Started	2014-02-20 15:50
To Make the First Decision	2014-03-13 18:57
Return for Revision	2014-03-20 08:20
Revised	2014-04-10 08:41
Second Decision	2014-06-23 10:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:18
Articles in Press	2014-06-23 10:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 11:51
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53
Manuscript Source	Unsolicited Manuscript
All Author List	Hsi-Hsien Hsu, Wei-Wen Kuo, Da-Tong Ju, Yu-Lan Yeh, Chuan-Chou Tu, Ying-Lan Tsai, Chia-Yao Shen, Sheng-Huang Chang, Li-Chin Chung and Chih-Yang Huang
Funding Agency and Grant Number	Funding Agency Grant Number Taiwan Department of Health Clinical Trial and Research Center of Excellence MOHW103-TDU-B-212-11300
Corresponding Author	Chih-Yang Huang, PhD, Graduate Institute of Basic Medical Science, China Medical University, No. 91 Hsueh-Shih Road, Taichung 404, Taiwan. cyhuang@mail.cmu.edu.tw
Key Words	Estrogen; Estrogen agonist; Estrogen receptors; Human colon cancer cell; p53
Core Tip	The present study is to investigate the effects of 17?-estradiol via estrogen receptors or directly administration of ERs agonist on the development of human colorectal cancer, and to elucidate whether the effect was regulated by tumor suppressor gene p53. Here, our results showed that 17?-estradiol and/or ERs agonist treatment in human LoVo colorectal cancer cells could active p53, then up-regulated p21 and p27 protein levels, subsequently inhibited downstream target gene, cyclin D1, which regulated the cell proliferation.
Publish Date	2014-12-02 10:46
Citation	Hsu HH, Kuo WW, Ju DT, Yeh YL, Tu CC, Tsai YL, Shen CY, Chang SH, Chung CL, Huang CY. Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53. World J Gastroenterol 2014; 20(44): 16665-16673
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16665.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16665

Full Article (PDF)	WJG-20-16665.pdf
Full Article (Word)	WJG-20-16665.doc
Manuscript File	9597-Review.doc
Answering Reviewers	9597-Answering reviewers.pdf
Copyright License Agreement	9597-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9597-Language certificate.pdf
Peer-review Report	9597-Peer review.pdf
Scientific Misconduct Check	9597-CrossCheck.jpg
Scientific Editor Work List	9597-Scientific editor work list.pdf