Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	96022
Country	China

Received	2024-04-24 16:05
Peer-Review Started	2024-04-24 16:05
To Make the First Decision
Return for Revision	2024-06-27 20:24
Revised	2024-06-30 01:40
Second Decision	2024-07-24 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-24 07:23
Articles in Press	2024-07-24 07:23
Publication Fee Transferred	2024-07-29 13:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-14 02:45
Publish the Manuscript Online	2024-09-09 08:41

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Erythropoietin-induced hepatocyte receptor A2 regulates effect of pyroptosis on gastrointestinal colorectal cancer occurrence and metastasis resistance
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Kun Zhang, Ran Shi, Ruo-Yu Meng, Shui-Li Lin and Mei Zheng
ORCID	Author(s) ORCID Number Mei Zheng http://orcid.org/0009-0000-2180-9552
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Nurturing Fund of the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital QYPY2020NSFC0609
Corresponding Author	Mei Zheng, PhD, Doctor, Doctor, Department of Rehabilitation Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, No. 16766 Jingshi Road, Jinan 250014, Shandong Province, China. 17686689905@163.com
Key Words	Colorectal cancer; Pyroptosis; Erythropoietin-induced hepatocyte receptor A2; Tumor metastasis; Drug resistance
Core Tip	This study investigated the expression of erythropoietin-induced hepatocyte receptor A2 (EphA2) in gastrointestinal (GI) colorectal cancer (CRC) and the mechanism by which EphA2 regulates pyroptosis. By reviewing the relevant literature, we found that EphA2 regulates pyroptosis through a variety of signaling pathways (such as the phosphatidylinositol 3 kinase/protein kinase B and Ras/mitogen-activated protein kinase pathways), thereby affecting the survival, proliferation and metastasis of cancer cells. The abnormal expression of EphA2 is closely related to the malignant behavior of GI CRC, and EphA2 further regulates the tumor microenvironment and immune response through interactions with inflammatory factors (such as tumor necrosis factor-α and interferon-γ). Studies have shown that targeting EphA2 can induce pyrodeath in cells, improve the sensitivity of cancer cells to treatment, and subsequently inhibit the occurrence and metastasis of tumors. Therefore, an in-depth understanding of the molecular mechanism by which EphA2 regulates pyrodeath provides new ideas and potential targets for the treatment of GI CRC.
Publish Date	2024-09-09 08:41
Citation	<p>Zhang YK, Shi R, Meng RY, Lin SL, Zheng M. Erythropoietin-induced hepatocyte receptor A2 regulates effect of pyroptosis on gastrointestinal colorectal cancer occurrence and metastasis resistance. <i>World J Gastrointest Oncol</i> 2024; 16(9): 3781-3797</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i9/3781.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i9.3781

Full Article (PDF)	WJGO-16-3781-with-cover.pdf
Manuscript File	96022_Auto_Edited_073505.docx
Answering Reviewers	96022-answering-reviewers.pdf
Audio Core Tip	96022-audio.mp3
Conflict-of-Interest Disclosure Form	96022-conflict-of-interest-statement.pdf
Copyright License Agreement	96022-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96022-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	96022-non-native-speakers.pdf
Peer-review Report	96022-peer-reviews.pdf
Scientific Misconduct Check	96022-scientific-misconduct-check.png
Scientific Editor Work List	96022-scientific-editor-work-list.pdf
CrossCheck Report	96022-crosscheck-report.pdf