Publication Name	World Journal of Gastroenterology
Manuscript ID	9603
Country	China

Received	2014-02-20 06:21
Peer-Review Started	2014-02-20 08:29
To Make the First Decision	2014-03-27 21:14
Return for Revision	2014-03-31 10:10
Revised	2014-05-09 00:00
Second Decision	2014-07-11 17:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:08
Articles in Press	2014-07-11 17:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-26 00:17
Typeset the Manuscript	2014-08-06 18:18
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Evidence-Based Medicine
Article Title	Perinodular ductular reaction/epithelial cell adhesion molecule loss in small hepatic nodules
Manuscript Source	Unsolicited Manuscript
All Author List	Qin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Feng-Mei Wang, Ying-Tang Gao and Zhi Du
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Tianjin Science and Technology Committee 05YFSZSF02500 Foundation of Tianjin 08JCYBJC08300 Key Research Project of Tianjin Healthy Bureau 11KG112
Corresponding Author	Zhi Du, PhD, Professor of Hepatobiliary Surgery, Key Laboratory of Artificial Cell, Institute for Hepatobiliary Diseases, the Third Central Hospital of Tianjin Medical University, No. 83 Jintang Road, Tianjin 300170, China. zhi-du@163.com
Key Words	Ductular reaction; Epithelial cell adhesion molecule; Hepatocellular carcinomas; Small hepatic nodule; Microinvasion; Differential diagnosis
Core Tip	Epithelial cell adhesion molecule (EpCAM) may be a new marker of ductular reaction (DR) in routine pathology. We observed the morphological features of DR/EpCAM in 112 small hepatic nodules and compared this with DR/cytokeratin 7 (CK7) and DR/cytokeratin 19 (CK19). The diagnostic value of DR/EpCAM was similar to DR/CK7 and DR/CK19; however, the diagnostic accuracy and specificity increased when these parameters were combined. Therefore, DR/EpCAM loss was confirmed to be a useful marker not only for determining microinvasion in HCCs ≤ 3 cm, but also for predicting prognosis.
Publish Date	2014-08-20 18:38
Citation	Zhang Q, Zhang CS, Xin Q, Ma Z, Liu GQ, Liu BB, Wang FM, Gao YT, Du Z. Perinodular ductular reaction/epithelial cell adhesion molecule loss in small hepatic nodules. World J Gastroenterol 2014; 20(31): 10908-10915
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10908.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10908

Full Article (PDF)	WJG-20-10908.pdf
Full Article (Word)	WJG-20-10908.doc
Manuscript File	9603-Review.doc
Answering Reviewers	9603-Answering reviewers.pdf
Copyright License Agreement	9603-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9603-Language certificate.PDF
Peer-review Report	9603-Peer review.pdf
Scientific Misconduct Check	9603-CrossCheck.jpg
Scientific Editor Work List	9603-Scientific editor work list.pdf