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Articles Published Processes
10/21/2024 7:03:24 AM | Browse: 115 | Download: 672
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Received |
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2024-04-28 10:28 |
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Peer-Review Started |
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2024-04-28 10:28 |
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First Decision by Editorial Office Director |
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2024-08-25 02:16 |
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Return for Revision |
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2024-08-25 02:16 |
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Revised |
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2024-09-12 07:04 |
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Publication Fee Transferred |
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2024-09-20 01:01 |
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Second Decision by Editor |
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2024-09-19 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-09-19 11:29 |
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Articles in Press |
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2024-09-19 11:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-10-11 02:01 |
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Publish the Manuscript Online |
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2024-10-21 07:03 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chun-Mei Li, Tian Sun, Mou-Jie Yang, Zhi Yang, Qing Li, Jia-Lin Shi, Chong Zhang and Jun-Fei Jin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangxi |
2020GXNSFDA238006 |
| Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department |
GuikeZY21195024 |
| Research Enhancement Project for Junior Faculty in Higher Education Institutes of Guangxi |
2018KY0419 |
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| Corresponding Author |
Jun-Fei Jin, PhD, Professor, Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, the Affiliated Hospital of Guilin Medical University, No. 15 Lequn Road, Guilin 541001, Guangxi Zhuang Autonomous Region, China. changliangzijin@163.com |
| Key Words |
C2-FH; Complement; Complement activation; Acetaminophen-induced liver injury; Inflammation |
| Core Tip |
Acetaminophen (APAP) is frequently utilized as a non-prescription medication for reducing fever and relieving pain. However, excessive intake of APAP may result in acute liver injury, liver failure and even death. This study found that C2-FH improved APAP-induced liver injury by alleviating liver tissue injury, inflammation and reducing the accumulation of complement activated products. Our research provided evidence that C2-FH shows potential as a possible treatment for APAP-induced liver injury. |
| Publish Date |
2024-10-21 07:03 |
| Citation |
Li CM, Sun T, Yang MJ, Yang Z, Li Q, Shi JL, Zhang C, Jin JF. Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice. World J Hepatol 2024; 16(10): 1188-1198 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i10/1188.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i10.1188 |
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