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Articles Published Processes
9/26/2024 10:17:47 AM | Browse: 209 | Download: 847
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Received |
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2024-04-26 13:05 |
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Peer-Review Started |
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2024-04-26 13:05 |
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First Decision by Editorial Office Director |
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2024-08-11 01:58 |
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Return for Revision |
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2024-08-11 01:58 |
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Revised |
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2024-08-20 02:08 |
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Publication Fee Transferred |
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2024-08-28 08:31 |
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Second Decision by Editor |
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2024-08-28 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-08-28 07:40 |
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Articles in Press |
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2024-08-28 07:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-08-30 10:12 |
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Publish the Manuscript Online |
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2024-09-26 10:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Gang He, Ling-Yu Zhang, Jing Li, Zheng Wang, Chong-Yu Zhao, Lu Zheng and Xiao-Bing Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Natural Science Foundation Project |
No. CSTB2022NSCQ-MSX0172 |
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| Corresponding Author |
Lu Zheng, MD, PhD, Chief Doctor, Department of Hepatobiliary, The Second Affiliated Hospital of Army Medical University, No. 83 Xinqiaozheng Street, Shapingbei District, Chongqing 400037, China. zhenglu@tmmu.edu.cn |
| Key Words |
Patient-derived organoids; Perihilar cholangiocarcinoma; Conversion therapy; Drug screening; Intrahepatic metastasis; Case report |
| Core Tip |
The patient-derived organoids (PDOs) have been demonstrated to predict the response to drugs in multiple cancer types. Here we first descried a patient with advanced perihilar cholangiocarcinoma (pCCA) who successfully underwent surgical resection after use of the PDO-guided gemcitabine and cisplatin in combination with toripalimab and lenvatinib and achieved good prognosis. For advanced pCCA patients, the PDO-based drug sensitivity testing contributes to screening effective chemotherapy drugs to promote the personalized treatment, which not only creates opportunities for surgical resection by lessening the tumor, but also offers a novel platform for improving the patient’s prognosis. |
| Publish Date |
2024-09-26 10:17 |
| Citation |
He YG, Zhang LY, Li J, Wang Z, Zhao CY, Zheng L, Huang XB. Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids: A case report. World J Gastrointest Oncol 2024; 16(10): 4274-4280 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i10/4274.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i10.4274 |
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