Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	9613
Country	Brazil

Received	2014-02-20 14:22
Peer-Review Started	2014-02-20 17:40
To Make the First Decision	2014-03-26 15:16
Return for Revision	2014-03-31 16:24
Revised	2014-04-18 12:48
Second Decision	2014-06-11 13:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 13:43
Articles in Press	2014-06-11 13:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-30 10:28
Publish the Manuscript Online	2014-07-20 20:11

ISSN	1948-9366 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Case Report
Article Title	Downstaging and resection after neoadjuvant therapy for fibrolamellar hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Gilton Marques Fonseca, Antonio Drauzio Varella, Fabricio Ferreira Coelho, Emerson Shigueaki Abe, Rodrigo Blanco Dumarco and Paulo Herman
Funding Agency and Grant Number
Corresponding Author	Gilton Marques Fonseca, MD, Digestive Surgery Division, Department of Gastroenterology, University of S?o Paulo School of Medicine, Avenida Doutor Enéas de Carvalho Aguiar, 255, Instituto Central, 9° Andar, Sala 9074, 05403-900, S?o Paulo, Brazil. medgilton@yahoo.com.br
Key Words	Chemotherapy; Gemcitabine; Oxaliplatin; Hepatectomy; Hepatic veins; Fibrolamellar hepatocellular carcinoma
Core Tip	Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare malignant liver neoplasm. The best treatment option is a surgical resection with liver hilum lymph node dissection. Currently there is no established systemic drug treatment for patients with locally advanced or metastatic disease. In this report, a patient with advanced FLHCC, initially considered unresectable due to vascular invasion, exhibited a significant tumor reduction following systemic chemotherapy with gemcitabine-oxaliplatin, allowing resection. This was an unusual case where gemcitabine-oxaliplatin treatment led to a significant tumor downstaging enabling curative resection. Additional studies are needed to confirm the efficacy of the systemic drug treatment for FLHCC.
Publish Date	2014-07-20 20:11
Citation	Fonseca GM, Varella AD, Coelho FF, Abe ES, Dumarco RB, Herman P. Downstaging and resection after neoadjuvant therapy for fibrolamellar hepatocellular carcinoma. World J Gastrointest Surg 2014; 6(6): 107-111
URL	http://www.wjgnet.com/1948-9366/full/v6/i6/107.htm
DOI	http://dx.doi.org/10.4240/wjgs.v6.i6.107

Full Article (PDF)	WJGS-6-107.pdf
Full Article (Word)	WJGS-6-107.doc
Manuscript File	9613-Review.doc
Answering Reviewers	9613-Answering reviewers.pdf
Copyright License Agreement	9613-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9613-Language certificate.pdf
Peer-review Report	9613-Peer review(s).pdf
Scientific Misconduct Check	9613-CrossCheck.jpg
Scientific Editor Work List	9613-Scientific editor work list.pdf