| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic bladder hyperactivity by reducing TRPV1 and P2X3
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guang-Yong Li, Shuai Ren, Bin-Cheng Huang, Jia-Jin Feng, Qiang-Qiang Wang, Qing-Jie Peng, Hai-Fu Tian, Le-Yi Yu, Cun-Ling Ma, Shu-Zhe Fan, Xiao-Jiang Chen, Mohammed Abdulkarem Al-Qaisi and Rui He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81860268 |
| National Natural Science Foundation of China |
82201000 |
| Ningxia Natural Science Foundation |
2021AAC02025 |
| Ningxia Science and Technology Innovation Leading Talent Training Project |
2020GKLRLX06 |
| Ningxia Science and Technology Innovation Leading Talent Training Project |
2020GKLRLX11 |
| Ningxia Medical University Research Project |
XJKF240315 |
| Ningxia Key Research and Development Project |
2023BEG03021 |
| Ningxia Key Research and Development Project |
2021BEB04034 |
|
| Corresponding Author |
Rui He, PhD, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, No. 1160 Shengli South Street, Xingqing District, Yinchuan 750000, Ningxia Hui Autonomous Region, China. ruihe515@163.com |
| Key Words |
Roux-en-Y gastric bypass; Diabetes; Bladder; Transient receptor potential vanilloid type 1; P2X3 |
| Core Tip |
Roux-en-Y gastric bypass (RYGB) as a metabolic surgery, effectively alleviates complications associated with diabetes. Although the mechanisms underlying diabetes-induced overactive bladder (OAB) remain unclear, this study finds that RYGB improves OAB symptoms by suppressing inflammatory cytokines, reducing transient receptor potential vanilloid type 1 expression, and inhibiting ATP synthesis in bladder epithelial cells, ultimately leading to a direct inhibition of P2X3 activity. |
| Publish Date |
2025-02-28 10:47 |
| Citation |
Li GY, Ren S, Huang BC, Feng JJ, Wang QQ, Peng QJ, Tian HF, Yu LY, Ma CL, Fan SZ, Chen XJ, Al-Qaisi MA, He R. Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic bladder hyperactivity by reducing TRPV1 and P2X3. World J Diabetes 2025; 16(4): 96176 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i4/96176.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i4.96176 |
