Publication Name	World Journal of Clinical Oncology
Manuscript ID	96177
Country	China

Received	2024-04-28 15:52
Peer-Review Started	2024-04-28 15:52
To Make the First Decision
Return for Revision	2024-06-29 04:12
Revised	2024-07-10 14:53
Second Decision	2024-07-25 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-25 06:12
Articles in Press	2024-07-25 06:12
Publication Fee Transferred	2024-07-25 17:16
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-12 07:31
Publish the Manuscript Online	2024-08-16 08:03

ISSN	2218-4333 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics
Manuscript Source	Unsolicited Manuscript
All Author List	Gan-Bin Li, Wei-Kun Shi, Xiao Zhang, Xiao-Yuan Qiu and Guo-Le Lin
ORCID	Author(s) ORCID Number Gan-Bin Li http://orcid.org/0000-0002-2576-1100 Wei-Kun Shi http://orcid.org/0000-0003-0413-6987 Xiao-Yuan Qiu http://orcid.org/0000-0003-1494-9068 Guo-Le Lin http://orcid.org/0000-0001-6225-3028
Funding Agency and Grant Number	Funding Agency Grant Number the National High Level Hospital Clinical Research Funding 2022-PUMCH-C-005
Corresponding Author	Guo-Le Lin, MD, PhD, Surgeon, Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. linguole@126.com
Key Words	Locally advanced rectal cancer; Neoadjuvant chemoradiotherapy; Poor-responders; Good responders; Exosome miRNA
Core Tip	Neoadjuvant chemoradiotherapy (nCRT) is the standard of care for the management of locally advanced rectal cancer; however, chemoresistance remains a life-threatening problem in patients with colorectal cancer. In this study, we used RNA sequencing to identify the expression profiles of plasma exosomal microRNAs (miRNAs) in two dimensions, according to treatment response (poor/good responders) and treatment course (pre/post-nCRT). Exosome hsa-miR-483-5p was upregulated in good responders post-nCRT and was chosen for further analysis. A network of hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 was constructed using bioinformatic analysis in terms of survival, stage, and drug sensitivity. This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs. However, further research is required within the framework of our established miRNA-mRNA network.
Publish Date	2024-08-16 08:03
Citation	<p>Li GB, Shi WK, Zhang X, Qiu XY, Lin GL. Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics. <i>World J Clin Oncol</i> 2024; 15(8): 1061-1077</p>
URL	https://www.wjgnet.com/2218-4333/full/v15/i8/1061.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i8.1061

Full Article (PDF)	WJCO-15-1061-with-cover.pdf
Manuscript File	96177_Auto_Edited_062646.docx
Answering Reviewers	96177-answering-reviewers.pdf
Audio Core Tip	96177-audio.mp3
Biostatistics Review Certificate	96177-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96177-conflict-of-interest-statement.pdf
Copyright License Agreement	96177-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96177-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	96177-non-native-speakers.pdf
Supplementary Material	96177-supplementary-material.pdf
Peer-review Report	96177-peer-reviews.pdf
Scientific Misconduct Check	96177-scientific-misconduct-check.png
Scientific Editor Work List	96177-scientific-editor-work-list.pdf
CrossCheck Report	96177-crosscheck-report.pdf
CrossCheck Report	96177-crosscheck-report.png