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Articles Published Processes
8/29/2024 6:31:20 AM | Browse: 67 | Download: 144
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Received |
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2024-05-01 06:50 |
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Peer-Review Started |
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2024-05-01 06:50 |
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To Make the First Decision |
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Return for Revision |
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2024-05-16 19:12 |
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2024-05-26 21:32 |
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Second Decision |
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2024-06-14 02:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-06-14 09:37 |
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Articles in Press |
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2024-06-14 09:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2024-06-24 00:19 |
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Typeset the Manuscript |
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2024-07-01 00:54 |
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Publish the Manuscript Online |
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2024-08-29 06:31 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Aryl hydrocarbon receptor dynamics in esophageal squamous cell carcinoma: From immune modulation to therapeutic opportunities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mina Rahmati, Hassan Moghtaderi, Saeed Mohammadi and Ahmed Al-Harrasi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ahmed Al-Harrasi, PhD, Full Professor, Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mauz, PO Box 33, Postal Code 616, Nizwa 616, Ad Dakhiliyah, Oman. aharrasi@unizwa.edu.om |
| Key Words |
Esophageal squamous cell carcinoma; Aryl hydrocarbon receptor; Immune escape; Tumor microenvironment; Immunosuppression; Therapeutic targeting |
| Core Tip |
Esophageal squamous cell carcinoma (ESCC) utilizes immune escape mechanisms, including major histocompatibility complex downregulation and immune checkpoint manipulation, which enhances tumor progression. The Aryl Hydrocarbon Receptor (AhR), which is crucial in health and disease, significantly influences ESCC development and immune evasion through carcinogenic pathways. AhR activation triggers proliferation, inhibits apoptosis, and induces epithelial-mesenchymal transition. Moreover, AhR suppresses effector T cells and enrolls immunosuppressive myeloid cells. Therapeutic AhR targeting with AhR ligands showed promise in inhibiting tumor growth, controlling the immune microenvironment, and enhancing treatment efficacy. Combining AhR-targeted therapies with conventional treatments or dietary interventions has the potential to improve ESCC patient outcomes. |
| Publish Date |
2024-08-29 06:31 |
| Citation |
<p>Rahmati M, Moghtaderi H, Mohammadi S, Al-Harrasi A. Aryl hydrocarbon receptor dynamics in esophageal squamous cell carcinoma: From immune modulation to therapeutic opportunities. <i>World J Exp Med</i> 2024; 14(3): 96269</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v14/i3/96269.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v14.i3.96269 |
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