Publication Name	World Journal of Psychiatry
Manuscript ID	96275
Country	China

Received	2024-05-01 13:57
Peer-Review Started	2024-05-01 13:58
To Make the First Decision
Return for Revision	2024-07-30 06:55
Revised	2024-08-24 15:33
Second Decision	2024-09-14 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-14 08:27
Articles in Press	2024-09-14 08:27
Publication Fee Transferred	2024-09-18 05:52
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-29 07:37
Publish the Manuscript Online	2024-11-27 10:57

ISSN	2220-3206 (online)
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Category	Psychiatry
Manuscript Type	Case Control Study
Article Title	Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Jun Cui, Li-Li Cai, Wan-Qiu Na, Rui-Long Jia, Jie-Lin Zhu and Xin Pan
ORCID	Author(s) ORCID Number Li-Jun Cui http://orcid.org/0009-0004-9009-0894 Xin Pan http://orcid.org/0009-0007-9429-2436
Funding Agency and Grant Number	Funding Agency Grant Number Huzhou Public Welfare Research Project Social Development Category 2021GYB09 Huzhou Public Welfare Research Project Social Development Category 2021GY38 Huzhou Public Welfare Research Project Social Development Category 2019GY26 Huzhou Public Welfare Research Project Social Development Category 2019GZB02
Corresponding Author	Xin Pan, Doctor, Chief Doctor, Department of Psychiatry, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, No. 2088 East Tiaoxi Road, Huzhou 313000, Zhejiang Province, China. huzhoupanxin@163.com
Key Words	Brain-derived neurotrophic factor; Inflammatory cytokines; First-episode schizophrenia; Cognitive function; Pro-inflammatory cytokines; Neuroinflammation; Serum biomarkers
Core Tip	The previous literature has demonstrated that dysregulation of the inflammatory immune and alterations in brain derived neurotrophic factor (BDNF) levels play a pivotal role in the pathophysiology of schizophrenia (SCZ). In this study, 84 patients with first-episode SCZ and 80 healthy volunteers were recruited. We assessed the cognitive function and psychiatric symptoms of the subjects, measured their serum inflammatory cytokines and BDNF levels, and explored the interaction between cognitive impairment and serum inflammatory cytokines and BDNF in first-episode SCZ. The findings of this study suggest that cognitive impairment in first-episode SCZ was related to immune inflammation imbalance and neurotrophic deficiency.
Publish Date	2024-11-27 10:57
Citation	<p>Cui LJ, Cai LL, Na WQ, Jia RL, Zhu JL, Pan X. Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients. <i>World J Psychiatry</i> 2024; 14(12): 1804-1814</p>
URL	https://www.wjgnet.com/2220-3206/full/v14/i12/1804.htm
DOI	https://dx.doi.org/10.5498/wjp.v14.i12.1804

Full Article (PDF)	WJP-14-1804-with-cover.pdf
STROBE Statement	96275-STROBE-statement.pdf
Manuscript File	96275_Auto_Edited_072532.docx
Answering Reviewers	96275-answering-reviewers.pdf
Audio Core Tip	96275-audio.mp3
Biostatistics Review Certificate	96275-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96275-conflict-of-interest-statement.pdf
Copyright License Agreement	96275-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96275-foundation-statement.PDF
Signed Informed Consent Form(s) or Document(s)	96275-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	96275-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	96275-non-native-speakers.pdf
Peer-review Report	96275-peer-reviews.pdf
Scientific Misconduct Check	96275-scientific-misconduct-check.png
Scientific Editor Work List	96275-scientific-editor-work-list.pdf
CrossCheck Report	96275-crosscheck-report.png
CrossCheck Report	96275-crosscheck-report.pdf