Publication Name	World Journal of Gastroenterology
Manuscript ID	96435
Country	United States

Received	2024-05-07 02:54
Peer-Review Started	2024-05-07 02:54
To Make the First Decision
Return for Revision	2024-09-15 23:40
Revised	2024-09-19 23:36
Second Decision	2024-09-25 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-25 06:31
Articles in Press	2024-09-25 06:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-30 04:51
Publish the Manuscript Online	2024-10-12 03:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions
Manuscript Source	Invited Manuscript
All Author List	Seok-Chan Park, Yu Ji Kim and Jong-Won Kim
ORCID	Author(s) ORCID Number Jong-Won Kim http://orcid.org/0009-0008-1219-6967
Funding Agency and Grant Number	Funding Agency Grant Number Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) HI22C2101 Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) HI20C0209
Corresponding Author	Jong-Won Kim, PhD, Research Assistant Professor, Research Associate, Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, 335 Sutherland Dr., Pittsburgh, PA 15216, United States. kjw@jbnu.ac.kr
Key Words	Uridine diphosphate glucuronosyltransferase 1A1; Liver injury; Endoplasmic reticulum stress; Oxidative stress; Lipid metabolism disorders
Core Tip	During liver injury, expression of the UGT1A1 enzyme increases. Interfering with this increase in expression can potentially worsen liver damage. The beneficial effects of UGT1A1 in reducing liver injury might stem from its capacity to alleviate hepatocyte apoptosis and necroptosis, which are driven by endoplasmic reticulum stress, oxidative stress, and abnormal lipid metabolism.
Publish Date	2024-10-12 03:43
Citation	<p>Park SC, Kim YJ, Kim JW. Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions. <i>World J Gastroenterol</i> 2024; 30(39): 4305-4307</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i39/4305.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i39.4305

Full Article (PDF)	WJG-30-4305-with-cover.pdf
Manuscript File	96435_Auto_Edited_092114.docx
Answering Reviewers	96435-answering-reviewers.pdf
Audio Core Tip	96435-audio.m4a
Conflict-of-Interest Disclosure Form	96435-conflict-of-interest-statement.pdf
Copyright License Agreement	96435-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96435-foundation-statement.pdf
Peer-review Report	96435-peer-reviews.pdf
Scientific Misconduct Check	96435-scientific-misconduct-check.png
Scientific Editor Work List	96435-scientific-editor-work-list.pdf
CrossCheck Report	96435-crosscheck-report.pdf