Publication Name	World Journal of Dermatology
Manuscript ID	9644
Country	United States

Received	2014-02-22 11:38
Peer-Review Started	2014-02-22 19:48
To Make the First Decision	2014-03-26 15:15
Return for Revision	2014-04-15 01:40
Revised	2014-05-20 00:00
Second Decision	2014-06-27 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-27 18:04
Articles in Press	2014-06-27 18:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-14 16:21
Publish the Manuscript Online	2014-08-28 16:04

ISSN	2218-6190 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Dermatology
Manuscript Type	Autobiography
Article Title	d-limonene prevents ultraviolet irradiation: Induced cyclobutane pyrimidine dimers in Skh1 mouse skin
Manuscript Source	Unsolicited Manuscript
All Author List	Ahmed N Uddin, Feng Wu, Ivica Labuda, Kam-Meng Tchou-Wong and Fredric J Burns
Funding Agency and Grant Number	Funding Agency Grant Number NCI Center Grant CA16087 NIEHS Center Grant and Biokeys for Flavors, LLC ES00260
Corresponding Author	Fredric J Burns, PhD, Professor, Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, United States. fredric.burns@nyumc.org
Key Words	Sunburn; Ultraviolet irradiation; d-limonene; Cyclobutane pyrimidine dimers; N-myc downstream regulating gene 1; Proliferating cell nuclear antigen
Core Tip	Skh-1 hairless mice were given 4 daily 20 ?L aliquots of different concentrations of d-limonene, and then irradiated to a single ultraviolet irradiation. Skin samples from the ultraviolet-exposed area of mice showed that ultraviolet irradiation induced cyclobutane pyrimidine dimers formation, N-myc downstream regulating gene 1 and proliferating cell nuclear antigen expression, pretreatment of d-limonene significantly reduced these responses. Pure d-limonene also induced the expression of epidermal barrier protein filaggrin. In conclusion, d-limonene protected the mice skin from UV-induced DNA photodamage and sunburn in mice skin.
Publish Date	2014-08-28 16:04
Citation	Uddin AN, Wu F, Labuda I, Tchou-Wong KM, Burns FJ. d-limonene prevents ultraviolet irradiation: Induced cyclobutane pyrimidine dimers in Skh1 mouse skin. World J Dermatol 2014; 3(3): 64-72
URL	http://www.wjgnet.com/2218-6190/full/v3/i3/64.htm
DOI	http://dx.doi.org/10.5314/wjd.v3.i3.64

Full Article (PDF)	WJD-3-64.pdf
Full Article (Word)	WJD-3-64.doc
Manuscript File	9644-Review.docx
Answering Reviewers	9644-Answering reviewers.pdf
Copyright License Agreement	9644-Copyright assignment.pdf
Peer-review Report	9644-Peer review(s).pdf
Scientific Misconduct Check	9644-CrossCheck.jpg
Scientific Editor Work List	9644-Scientific editor work list.pdf