Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	96446
Country	United States

Received	2024-05-07 09:00
Peer-Review Started	2024-05-07 09:00
To Make the First Decision
Return for Revision	2024-06-03 01:59
Revised	2024-09-04 16:31
Second Decision	2024-09-13 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-13 09:32
Articles in Press	2024-09-13 09:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-18 07:37
Publish the Manuscript Online	2024-09-20 09:35

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Microbiome as an endocrine organ and its relationship with eye diseases: Effective factors and new targeted approaches
Manuscript Source	Invited Manuscript
All Author List	Leila Haghshenas, Sara Banihashemi, Yalda Malekzadegan, Roberto Catanzaro, Amir Moghadam Ahmadi and Francesco Marotta
ORCID	Author(s) ORCID Number Leila Haghshenas http://orcid.org/0000-0002-4883-5977 Roberto Catanzaro http://orcid.org/0000-0003-4852-9125
Funding Agency and Grant Number
Corresponding Author	Leila Haghshenas, PhD, Assistant Professor, Department of Clinical Bioinformatics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States. leilahagh@yahoo.com
Key Words	Dysbiosis; Gut microbiome; Eye diseases; Inflammation; Diabetic retinopatyhy; Aging; Nutrient supplementation
Core Tip	In this article, we reviewed the content of the studies conducted in the field of intestinal microbiome and eye diseases and stated that the intestinal microbiome acts like an endocrine gland that regulates hormonal and humoral factors to regulate the innate immune system in processes related to metabolism. We reviewed dysbiosis, which causes changes in small secretory molecules in the digestive area and intestinal lumen leakage and the occurrence of diseases in all body organs, including eye diseases. We investigated latest important studies related to environmental, food and drugs in relation to intestinal microbiome and eye diseases.
Publish Date	2024-09-20 09:35
Citation	<p>Haghshenas L, Banihashemi S, Malekzadegan Y, Catanzaro R, Moghadam Ahmadi A, Marotta F. Microbiome as an endocrine organ and its relationship with eye diseases: Effective factors and new targeted approaches. <i>World J Gastrointest Pathophysiol</i> 2024; 15(5): 96446</p>
URL	https://www.wjgnet.com/2150-5330/full/v15/i5/96446.htm
DOI	https://dx.doi.org/10.4291/wjgp.v15.i5.96446

Full Article (PDF)	WJGP-15-96446-with-cover.pdf
Manuscript File	96446_Auto_Edited_033906.docx
Answering Reviewers	96446-answering-reviewers.pdf
Audio Core Tip	96446-audio.mp4
Conflict-of-Interest Disclosure Form	96446-conflict-of-interest-statement.pdf
Copyright License Agreement	96446-copyright-assignment.pdf
Supplementary Material	96446-supplementary-material.pdf
Peer-review Report	96446-peer-reviews.pdf
Scientific Misconduct Check	96446-scientific-misconduct-check.png
Scientific Editor Work List	96446-scientific-editor-work-list.pdf
CrossCheck Report	96446-crosscheck-report.png
CrossCheck Report	96446-crosscheck-report.pdf