Publication Name	World Journal of Gastroenterology
Manuscript ID	96459
Country	China

Received	2024-05-07 12:46
Peer-Review Started	2024-05-07 12:46
To Make the First Decision
Return for Revision	2024-11-26 06:13
Revised	2024-12-01 10:59
Second Decision	2024-12-27 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-27 08:23
Articles in Press	2024-12-27 08:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-08 10:54
Publish the Manuscript Online	2025-01-20 07:38

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Infectious Diseases
Manuscript Type	Basic Study
Article Title	Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway
Manuscript Source	Invited Manuscript
All Author List	Qian Chen, Ya-Li Zhang, Yong-Quan Shi and Lie Zheng
ORCID	Author(s) ORCID Number Qian Chen http://orcid.org/0000-0002-1598-2735 Ya-Li Zhang http://orcid.org/0000-0002-8987-3558 Yong-Quan Shi http://orcid.org/0000-0001-9515-7577 Lie Zheng http://orcid.org/0000-0002-0918-0728
Funding Agency and Grant Number	Funding Agency Grant Number Xi’an Science and Technology Plan Project 23YXYJ0162 Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project TZKN-CXRC-16 Project of Shaanxi Administration of Traditional Chinese Medicine SZY-KJCYC-2025-JC-010 Shaanxi Province Key Research and Development Plan Project-Social Development Field S2025-YF-YBSF-0391 the Science and Technology Innovation Cultivation Program of Longhua Hospital affiliated to Shanghai University of Chinese Medicine YD202220
Corresponding Author	Lie Zheng, PhD, Department of Gastroenterology, Traditional Chinese Medicine Hospital of Shaanxi Province, No. 4 Xihuamen, Lianhu District, Xi’an 710003, Shaanxi Province, China. 492688049@qq.com
Key Words	Mesalazine; Ulcerative colitis; Interleukin-10-/- mice; Signal transducer and activator of transcription 3/nuclear factor kappa B signaling pathway; Endoplasmic reticulum stress; Inflammatory bowel disease
Core Tip	Long-term and persistent excessive endoplasmic reticulum stress in IL-10-/- mice intestinal epithelial cells destroy the intestinal mucosal barrier and activates the signal transducer and activator of transcription 3/nuclear factor kappa B pathway, leading to the spontaneous generation of ulcerative colitis. Mesalazine could alleviate the symptoms of colitis in IL-10-/- mice, regulate endoplasmic reticulum stress and down-regulate the signal transducer and activator of transcription 3/nuclear factor kappa B pathway.
Publish Date	2025-01-20 07:38
Citation	<p>Chen Q, Zhang YL, Shi YQ, Zheng L. Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway. <i>World J Gastroenterol</i> 2025; 31(7): 96459</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i7/96459.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i7.96459

Full Article (PDF)	WJG-31-96459-with-cover.pdf
The ARRIVE Guidelines	96459-The-ARRIVE-Guidelines.pdf
Manuscript File	96459_Auto_Edited_010634.docx
Answering Reviewers	96459-answering-reviewers.pdf
Audio Core Tip	96459-audio.m4a
Biostatistics Review Certificate	96459-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96459-conflict-of-interest-statement.pdf
Copyright License Agreement	96459-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96459-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	96459-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	96459-non-native-speakers.pdf
Peer-review Report	96459-peer-reviews.pdf
Scientific Misconduct Check	96459-scientific-misconduct-check.png
Scientific Editor Work List	96459-scientific-editor-work-list.pdf
CrossCheck Report	96459-crosscheck-report.pdf