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Articles Published Processes
1/20/2025 7:38:46 AM | Browse: 133 | Download: 718
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Received |
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2024-05-07 12:46 |
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Peer-Review Started |
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2024-05-07 12:46 |
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First Decision by Editorial Office Director |
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2024-11-26 06:13 |
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Return for Revision |
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2024-11-26 06:13 |
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Revised |
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2024-12-01 10:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-12-27 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-12-27 08:23 |
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Articles in Press |
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2024-12-27 08:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-01-08 10:54 |
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Publish the Manuscript Online |
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2025-01-20 07:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qian Chen, Ya-Li Zhang, Yong-Quan Shi and Lie Zheng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Xi’an Science and Technology Plan Project |
23YXYJ0162 |
| Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project |
TZKN-CXRC-16 |
| Project of Shaanxi Administration of Traditional Chinese Medicine |
SZY-KJCYC-2025-JC-010 |
| Shaanxi Province Key Research and Development Plan Project-Social Development Field |
S2025-YF-YBSF-0391 |
| the Science and Technology Innovation Cultivation Program of Longhua Hospital affiliated to Shanghai University of Chinese Medicine |
YD202220 |
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| Corresponding Author |
Lie Zheng, PhD, Department of Gastroenterology, Traditional Chinese Medicine Hospital of Shaanxi Province, No. 4 Xihuamen, Lianhu District, Xi’an 710003, Shaanxi Province, China. 492688049@qq.com |
| Key Words |
Mesalazine; Ulcerative colitis; Interleukin-10-/- mice; Signal transducer and activator of transcription 3/nuclear factor kappa B signaling pathway; Endoplasmic reticulum stress; Inflammatory bowel disease |
| Core Tip |
Long-term and persistent excessive endoplasmic reticulum stress in IL-10-/- mice intestinal epithelial cells destroy the intestinal mucosal barrier and activates the signal transducer and activator of transcription 3/nuclear factor kappa B pathway, leading to the spontaneous generation of ulcerative colitis. Mesalazine could alleviate the symptoms of colitis in IL-10-/- mice, regulate endoplasmic reticulum stress and down-regulate the signal transducer and activator of transcription 3/nuclear factor kappa B pathway. |
| Publish Date |
2025-01-20 07:38 |
| Citation |
Chen Q, Zhang YL, Shi YQ, Zheng L. Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway. World J Gastroenterol 2025; 31(7): 96459 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i7/96459.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i7.96459 |
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