BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/29/2024 2:50:18 PM | Browse: 168 | Download: 1179
 |
Received |
|
2024-05-07 14:38 |
|
Peer-Review Started |
|
2024-05-07 14:38 |
|
First Decision by Editorial Office Director |
|
2024-08-25 02:14 |
|
Return for Revision |
|
2024-08-25 02:14 |
|
Revised |
|
2024-08-31 14:23 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2024-09-18 02:41 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2024-09-19 12:34 |
|
Articles in Press |
|
2024-09-19 12:34 |
|
Edit the Manuscript by Language Editor |
|
2024-10-28 22:25 |
|
Typeset the Manuscript |
|
2024-11-22 00:42 |
|
Publish the Manuscript Online |
|
2024-11-29 14:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Felipe Schütz, Larisse Longo, Melina Belén Keingeski, Eduardo Filippi-Chiela, Carolina Uribe-Cruz and Mário Reis Álvares-da-Silva |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Financiamento e Incentivo à Pesquisa from Hospital de Clínicas de Porto Alegre (FIPE/HCPA) |
2022-0117 |
| National Council for Scientific and Technological Development |
CNPq |
| Coordination for the Improvement of Higher Education Personnel |
CAPES/PNPD |
|
| Corresponding Author |
Mário Reis Álvares-da-Silva, MD, PhD, Professor, Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n° 2350/Sala 2033, 2° Andar, Porto Alegre 90035-007, Rio Grande do Sul, Brazil. marioreis@live.com |
| Key Words |
Animal model; Epigenetic; Lipophagy; MicroRNAs; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis |
| Core Tip |
This nutritional model of metabolic dysfunction-associated steatohepatitis (MASH) is useful for evaluating pathophysiological mechanisms and therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). Animals with MASH showed increased expression of miR-34a and miR-21, markers that contribute to the inflammatory process and fibrogenesis of the disease. Additionally, the lipophagy process was reduced due to increased perilipin gene expression and decreased Sirtuin-1. Lysosomal stress and autophagic activity increased in MASH, through increased expression of transcription factor-EB and decreased levels of p62/sequestosome-1. Alterations in the expression of these genes are related to the inflammatory process and fibrogenesis, processes that promote the progression of MASLD. |
| Publish Date |
2024-11-29 14:50 |
| Citation |
Schütz F, Longo L, Keingeski MB, Filippi-Chiela E, Uribe-Cruz C, Álvares-da-Silva MR. Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model. World J Hepatol 2024; 16(12): 1468-1479 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i12/1468.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i12.1468 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
