Publication Name	World Journal of Hepatology
Manuscript ID	96462
Country	Brazil

Received	2024-05-07 14:38
Peer-Review Started	2024-05-07 14:38
To Make the First Decision
Return for Revision	2024-08-25 02:14
Revised	2024-08-31 14:23
Second Decision	2024-09-18 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-19 12:34
Articles in Press	2024-09-19 12:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-28 22:25
Typeset the Manuscript	2024-11-22 00:42
Publish the Manuscript Online	2024-11-29 14:50

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model
Manuscript Source	Unsolicited Manuscript
All Author List	Felipe Schütz, Larisse Longo, Melina Belén Keingeski, Eduardo Filippi-Chiela, Carolina Uribe-Cruz and Mário Reis Álvares-da-Silva
ORCID	Author(s) ORCID Number Larisse Longo http://orcid.org/0000-0002-4453-7227 Eduardo Filippi-Chiela http://orcid.org/0000-0001-8192-3779 Carolina Uribe-Cruz http://orcid.org/0000-0002-0526-3067 Mário Reis Álvares-da-Silva http://orcid.org/0000-0002-5001-246X
Funding Agency and Grant Number	Funding Agency Grant Number Financiamento e Incentivo à Pesquisa from Hospital de Clínicas de Porto Alegre (FIPE/HCPA) 2022-0117 National Council for Scientific and Technological Development CNPq Coordination for the Improvement of Higher Education Personnel CAPES/PNPD
Corresponding Author	Mário Reis Álvares-da-Silva, MD, PhD, Professor, Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n° 2350/Sala 2033, 2° Andar, Porto Alegre 90035-007, Rio Grande do Sul, Brazil. marioreis@live.com
Key Words	Animal model; Epigenetic; Lipophagy; MicroRNAs; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis
Core Tip	This nutritional model of metabolic dysfunction-associated steatohepatitis (MASH) is useful for evaluating pathophysiological mechanisms and therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). Animals with MASH showed increased expression of miR-34a and miR-21, markers that contribute to the inflammatory process and fibrogenesis of the disease. Additionally, the lipophagy process was reduced due to increased perilipin gene expression and decreased Sirtuin-1. Lysosomal stress and autophagic activity increased in MASH, through increased expression of transcription factor-EB and decreased levels of p62/sequestosome-1. Alterations in the expression of these genes are related to the inflammatory process and fibrogenesis, processes that promote the progression of MASLD.
Publish Date	2024-11-29 14:50
Citation	<p>Schütz F, Longo L, Keingeski MB, Filippi-Chiela E, Uribe-Cruz C, Álvares-da-Silva MR. Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model. <i>World J Hepatol</i> 2024; 16(12): 1468-1479</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i12/1468.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i12.1468

Full Article (PDF)	WJH-16-1468-with-cover.pdf
The ARRIVE Guidelines	96462-The-ARRIVE-Guidelines.pdf
Manuscript File	96462_Auto_Edited_063453.docx
Answering Reviewers	96462-answering-reviewers.pdf
Audio Core Tip	96462-audio.m4a
Biostatistics Review Certificate	96462-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96462-conflict-of-interest-statement.pdf
Copyright License Agreement	96462-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96462-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	96462-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	96462-non-native-speakers.pdf
Supplementary Material	96462-supplementary-material.pdf
Peer-review Report	96462-peer-reviews.pdf
Scientific Misconduct Check	96462-scientific-misconduct-check.png
Scientific Editor Work List	96462-scientific-editor-work-list.pdf
CrossCheck Report	96462-crosscheck-report.png
CrossCheck Report	96462-crosscheck-report.pdf