| ISSN |
2307-8960 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and comprehensively peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Chuan Yang, Xiang Ma, Chi Zhou, Nan Xu, Ding Ding, Zhong-Zheng Ma, Lei Zhou and Pei-Yuan Cui |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| School-Level Key Projects at Bengbu Medical College |
2021byzd109 |
|
| Corresponding Author |
Pei-Yuan Cui, MD, Chief Doctor, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. cpy666@126.com |
| Key Words |
Primary biliary cholangitis; Weighted gene co-expression network analysis; Hub genes; Mendelian randomization; Bioinformatic analysis |
| Core Tip |
This study identified five hub genes (CD247, IL10, CCL5, CCL3, and STAT3) associated with primary biliary cholangitis (PBC) through comprehensive bioinformatics analysis. These hub genes were enriched in immune-related pathways and strongly correlated with immune cell infiltration in PBC. Although hub genes did not have a causal effect on PBC risk, they provided valuable insights into the molecular mechanisms of PBC and showed potential as biomarkers for PBC prediction and treatment. |
| Publish Date |
2024-09-04 06:40 |
| Citation |
<p>Yang YC, Ma X, Zhou C, Xu N, Ding D, Ma ZZ, Zhou L, Cui PY. Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes. <i>World J Clin Cases</i> 2024; 12(30): 6391-6406</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i30/6391.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i30.6391 |
