Publication Name	World Journal of Orthopedics
Manuscript ID	96484
Country	Saudi Arabia

Received	2024-05-07 20:06
Peer-Review Started	2024-05-07 20:06
To Make the First Decision
Return for Revision	2024-07-21 15:36
Revised	2024-08-13 08:36
Second Decision	2024-10-09 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-09 07:29
Articles in Press	2024-10-09 07:29
Publication Fee Transferred	2024-10-12 18:48
Edit the Manuscript by Language Editor	2024-10-21 21:20
Typeset the Manuscript	2024-11-12 01:12
Publish the Manuscript Online	2024-11-15 09:06

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis
Manuscript Source	Unsolicited Manuscript
All Author List	Usama Ismaeil Hagag, Fatma Mohamed Halfaya, Hessah Mohammed Al-Muzafar, Suhailah Saud Al-Jameel, Kamal Adel Amin, Wael Abou El-Kheir, Emad A Mahdi, Gamal Abdel-Nasser Ragab Hassan and Osama Mohamed Ahmed
ORCID	Author(s) ORCID Number Kamal Adel Amin http://orcid.org/0000-0003-2487-8427 Osama Mohamed Ahmed http://orcid.org/0000-0003-3781-9709
Funding Agency and Grant Number
Corresponding Author	Kamal Adel Amin, PhD, Department of Chemistry, Biochemistry, College of Science, Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, PO Box 1982, Dammam 31441, Saudi Arabia. kaothman@iau.edu.sa
Key Words	Osteoarthritis; Anti-inflammatory; Antioxidant; Bone marrow mesenchymal stem cells; Hyaluronic acid
Core Tip	In this study, we determined the effectiveness of bone marrow mesenchymal stem cells and/or hyaluronic acid in treating experimental ankle osteoarthritis. Bone marrow mesenchymal stem cells (BMMSCs) characterized by Flow cytometry and animals divided into 5 groups. Lipid peroxidation, MMP-13 mRNA, transforming growth factor-β (TGF-β1) protein expressions, tumor necrosis factor-α and interleukin-17 serum levels significantly increased in osteoarthritic rats while Antioxidant serum glutathione and glutathione transferase levels decreased. The treatment of osteoarthritic rats with BMMSCs and hyaluronic acid (HA) significantly improved these changes. BMMSC and/or HA consider a novel anti-arthritic effect mediated by the augmentation of the antioxidant and anti-inflammatory and suppression of MMP-13 and TGF-β1 expressions in Wistar rats with OA.
Publish Date	2024-11-15 09:06
Citation	<p>Hagag UI, Halfaya FM, Al-Muzafar HM, Al-Jameel SS, Amin KA, Abou El-Kheir W, Mahdi EA, Hassan GANR, Ahmed OM. Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis. <i>World J Orthop</i> 2024; 15(11): 1056-1074</p>
URL	https://www.wjgnet.com/2218-5836/full/v15/i11/1056.htm
DOI	https://dx.doi.org/10.5312/wjo.v15.i11.1056

Full Article (PDF)	WJO-15-1056-with-cover.pdf
The ARRIVE Guidelines	96484-The-ARRIVE-Guidelines.pdf
Manuscript File	96484_Auto_Edited_011119.docx
Answering Reviewers	96484-answering-reviewers.pdf
Audio Core Tip	96484-audio.mp3
Biostatistics Review Certificate	96484-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96484-conflict-of-interest-statement.pdf
Copyright License Agreement	96484-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	96484-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	96484-non-native-speakers.pdf
Peer-review Report	96484-peer-reviews.pdf
Scientific Misconduct Check	96484-scientific-misconduct-check.png
Scientific Editor Work List	96484-scientific-editor-work-list.pdf
CrossCheck Report	96484-crosscheck-report.pdf
CrossCheck Report	96484-crosscheck-report.png