Publication Name	World Journal of Hepatology
Manuscript ID	96506
Country	China

Received	2024-05-08 12:46
Peer-Review Started	2024-05-08 12:46
To Make the First Decision
Return for Revision	2024-09-02 01:11
Revised	2024-09-30 13:41
Second Decision	2025-01-02 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-02 06:58
Articles in Press	2025-01-02 06:58
Publication Fee Transferred	2025-01-06 07:28
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-21 03:29
Publish the Manuscript Online	2025-02-20 08:39

ISSN	1948-5182 (online)
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Category	Infectious Diseases
Manuscript Type	Retrospective Study
Article Title	Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Shuang Huang, Wei Gao, Ai-Jun Sun, Chun-Wen Pu and Shuang-Shuang Xu
ORCID	Author(s) ORCID Number Yu-Shuang Huang http://orcid.org/0000-0002-3765-1267 Wei Gao http://orcid.org/0000-0003-0942-0119 Ai-Jun Sun http://orcid.org/0000-0003-4830-3249 Chun-Wen Pu http://orcid.org/0000-0001-6442-3393
Funding Agency and Grant Number	Funding Agency Grant Number “Climbing Program” Construction Project “High Peak Project” Department of Major Infectious Disease Prevention and Control
Corresponding Author	Ai-Jun Sun, Department of Infectious Diseases, Dalian Public Health Clinical Center, No. 269 Huibai Road, Lu Gang, Ganjingzi District, Dalian 116031, Liaoning Province, China. 2244518005@qq.com
Key Words	Hepatitis; Hepatitis B-related cirrhosis; Clinical features; Influencing factors; Nomogram
Core Tip	In order to analyze the clinical characteristics of patients with hepatitis and cirrhosis, a nomogram model was established and verified. The clinical records of 1070 patients with hepatitis B who were treated in our hospital were selected for study, and they were divided into 749 cases in the modeling cohort and 321 cases in the model validation cohort in a 7:3 ratio. At the same time, the model validation cohort was divided into hepatitis group (n = 688) and hepatitis cirrhosis group (n = 61), and the model validation cohort was divided into hepatitis group (n = 295) and hepatitis cirrhosis group (n = 26) according to whether the patients had liver cirrhosis. The levels of albumin hepatitis B E antigen, white blood cell, red blood cell, hemoglobin, absolute neutrophil count and absolute lymphocyte count in patients with hepatitis cirrhosis were significantly lower in the modeling cohort than those in patients with hepatitis, while the levels of the ratio of aspartate aminotransferase, plasma prothrombin time, hyaluronic acid, laminin and platelet count were significantly higher than those in patients with hepatitis (all P < 0.05). The area under the receiver operating characteristic curve (AUC) of the nomogram prediction model established by cohort modeling was 0.693 [95% confidence interval (CI): 0.631 to 0.756], and AUC of the nomogram prediction model was 0.675 (95%CI: 0.561 to 0.790). The actual result curves of the nomograms generated by the modeling and validation cohorts deviate from the calibration curves with little tolerance.
Publish Date	2025-02-20 08:39
Citation	<p>Huang YS, Gao W, Sun AJ, Pu CW, Xu SS. Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model. <i>World J Hepatol</i> 2025; 17(2): 96506</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i2/96506.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i2.96506

Full Article (PDF)	WJH-17-96506-with-cover.pdf
Manuscript File	96506_Auto_Edited_005253.docx
Answering Reviewers	96506-answering-reviewers.pdf
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Biostatistics Review Certificate	96506-biostatistics-statement.pdf
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Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96506-foundation-statement.pdf
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Institutional Review Board Approval Form or Document	96506-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	96506-non-native-speakers.pdf
Supplementary Material	96506-supplementary-material.pdf
Peer-review Report	96506-peer-reviews.pdf
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Scientific Editor Work List	96506-scientific-editor-work-list.pdf
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CrossCheck Report	96506-crosscheck-report.pdf