Publication Name	World Journal of Hepatology
Manuscript ID	9652
Country	Bangladesh

Received	2014-02-22 17:25
Peer-Review Started	2014-02-22 20:49
To Make the First Decision	2014-04-04 16:10
Return for Revision	2014-04-09 10:15
Revised	2014-05-23 00:00
Second Decision	2014-06-11 14:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 14:34
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-14 17:12
Typeset the Manuscript	2014-08-28 14:03
Publish the Manuscript Online	2014-08-29 07:54

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Early termination of immune tolerance state of hepatitis B virus infection explains liver damage
Manuscript Source	Invited Manuscript
All Author List	Mamun-Al-Mahtab, Sheikh Mohammad Fazle Akbar, Helal Uddin, Sakirul Islam Khan and Salimur Rahman
Funding Agency and Grant Number
Corresponding Author	Dr. Mamun-Al-Mahtab, Associate Professor of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh Rd, Dhaka 1000, Bangladesh. shwapnil@agni.com
Key Words	Chronic hepatitis B; Immune tolerance; Early termination
Core Tip	Immune tolerance phase usually prevails for up to 20-25 years in subjects with chronic hepatitis B virus (HBV) infection. However, the present study showed that considerable numbers of chronic HBV-infected patients of Bangladesh lost hepatitis B e antigen and developed anti-HBe. Early termination of immune tolerance phase of these young patients was also associated with elevated alanine aminotransferase, hepatic necroinflammation and considerable hepatic fibrosis in some patients. Treatment guidelines are warranted for these patients as there is a paucity of information about their entity.
Publish Date	2014-08-29 07:54
Citation	Mahtab MA, Akbar SMF, Uddin H, Khan SI, Rahman S. Early termination of immune tolerance state of hepatitis B virus infection explains liver damage. World J Hepatol 2014; 6(8): 621-625
URL	http://www.wjgnet.com/1948-5182/full/v6/i8/621.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i8.621

Full Article (PDF)	WJH-6-621.pdf
Full Article (Word)	WJH-6-621.doc
Manuscript File	9652-Review.docx
Answering Reviewers	9652-Answering reviewers.pdf
Copyright License Agreement	9652-Copyright assignment.pdf
Peer-review Report	9652-Peer review(s).pdf
Scientific Misconduct Check	9652-CrossCheck.jpg
Scientific Editor Work List	9652-Scientific editor work list.pdf