Publication Name	World Journal of Gastroenterology
Manuscript ID	9663
Country	Japan

Received	2014-02-27 20:30
Peer-Review Started	2014-03-01 10:26
To Make the First Decision	2014-03-13 18:48
Return for Revision	2014-03-23 17:18
Revised	2014-03-25 05:24
Second Decision	2014-06-05 10:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-05 10:51
Articles in Press	2014-06-05 11:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-02 08:02
Typeset the Manuscript	2014-10-24 18:53
Publish the Manuscript Online	2014-11-17 15:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs
Manuscript Source	Unsolicited Manuscript
All Author List	Hiroyuki Ando, Erito Mochiki, Tetsuro Ohno, Mitsuhiro Yanai, Yoshitaka Toyomasu, Kyoichi Ogata, Yuichi Tabe, Ryuusuke Aihara, Toshihiro Nakabayashi, Takayuki Asao and Hiroyuki Kuwano
Funding Agency and Grant Number
Corresponding Author	Hiroyuki Ando, MD, PhD, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. andu07120404andu@yahoo.co.jp
Key Words	Cisplatin; Emesis; 5-hydroxytryptamine; Abnormal motor activity; Dog
Core Tip	Previous studies have investigated the motility change unique to cisplatin-induced emesis. This study is the first to investigate whether 5-hydroxytryptamine (serotonin; 5-HT) is involved in mediating abnormal motor activity in dogs after cisplatin administration. Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 h. In normal dogs with resection of the vagus nerve that were administered 5-HT 3 receptor antagonist (kytril), cisplatin given intravenously did not produce abnormal motor activity. Abnormal motor activity was produced in the involved vagus nerve and in the involved serotonergic neurons via another pathway.
Publish Date	2014-11-17 15:12
Citation	Ando H, Mochiki E, Ohno T, Yanai M, Toyomasu Y, Ogata K, Tabe Y, Aihara R, Nakabayashi T, Asao T, Kuwano H. Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs. World J Gastroenterol 2014; 20(42): 15691-15702
URL	http://www.wjgnet.com/1007-9327/full/v20/i42/15691.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i42.15691

Full Article (PDF)	WJG-20-15691.pdf
Full Article (Word)	WJG-20-15691.doc
Manuscript File	9663-Review.doc
Answering Reviewers	9663-Answering reviewers.pdf
Copyright License Agreement	9663-Copyright assignment.pdf
Peer-review Report	9663-Peer review(s).pdf
Scientific Misconduct Check	9663-CrossCheck.jpg
Scientific Editor Work List	9663-Scientific editor work list.pdf