Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	96643
Country	Romania

Received	2024-05-11 18:41
Peer-Review Started	2024-05-11 18:41
To Make the First Decision
Return for Revision	2024-09-19 21:33
Revised	2024-10-03 20:05
Second Decision	2024-12-06 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-06 08:34
Articles in Press	2024-12-06 08:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-16 02:37
Publish the Manuscript Online	2024-12-20 07:07

ISSN	2219-2808 (online)
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Category	Pediatrics
Manuscript Type	Clinical Trials Study
Article Title	Autologous cord blood vs individualized supplements in autistic spectrum disorder: CORDUS study results
Manuscript Source	Invited Manuscript
All Author List	Felician A Stancioiu, Raluca Bogdan, Bogdan Ivanescu and Radu Dumitrescu
ORCID	Author(s) ORCID Number Felician A Stancioiu http://orcid.org/0000-0001-8398-388X Radu Dumitrescu http://orcid.org/0009-0008-4481-394X
Funding Agency and Grant Number
Corresponding Author	Felician A Stancioiu, MD, Department of Clinical Research, Bio-Forum Foundation, Splai Unirii Nr 8, Parter, Bucharest 040245, Bucuresti, Romania. felicians@bio-forum.net
Key Words	Autistic spectrum disorder; Cord blood; Stem cells; Neuroinflammation; Autologous stem cell treatment; Neuronal specific enolase
Core Tip	CORDUS clinical study aimed to find factors correlated to therapeutic efficacy in autistic spectrum disorder (ASD) by comparing sequential administration of autologous cord blood (ACB) and individualised supplements and testing both the ASD children and the ACB. High initial levels of inflammation markers (erythrocyte sedimentation rate, C-reactive protein, tumor necrosis factor-alpha, α-2 globulins) or ferritin, but not high initial levels of neuronal specific enolase (NSE), were correlated with little or no improvement after cord blood administration. In some patients NSE was lowered after ACB. In a few patients improvement on specific supplements was superior to cord blood. Further studies are needed for finding predictors of cord blood efficacy in ASD.
Publish Date	2024-12-20 07:07
Citation	<p>Stancioiu FA, Bogdan R, Ivanescu B, Dumitrescu R. Autologous cord blood vs individualized supplements in autistic spectrum disorder: CORDUS study results. <i>World J Clin Pediatr</i> 2025; 14(1): 96643</p>
URL	https://www.wjgnet.com/2219-2808/full/v14/i1/96643.htm
DOI	https://dx.doi.org/10.5409/wjcp.v14.i1.96643

Full Article (PDF)	WJCP-14-96643-with-cover.pdf
CONSORT 2010 Statement	96643-CONSORT-2010-statement.pdf
Manuscript File	96643_Auto_Edited_015335.docx
Answering Reviewers	96643-answering-reviewers.pdf
Audio Core Tip	96643-audio.m4a
Biostatistics Review Certificate	96643-biostatistics-statement.pdf
Clinical Trial Registration Statement	96643-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	96643-conflict-of-interest-statement.pdf
Copyright License Agreement	96643-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	96643-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	96643-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	96643-non-native-speakers.pdf
Peer-review Report	96643-peer-reviews.pdf
Scientific Misconduct Check	96643-scientific-misconduct-check.png
Scientific Editor Work List	96643-scientific-editor-work-list.pdf
CrossCheck Report	96643-crosscheck-report.pdf