Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	96680
Country	China

Received	2024-05-21 13:56
Peer-Review Started	2024-05-21 13:57
To Make the First Decision
Return for Revision	2024-06-18 06:30
Revised	2024-07-04 15:14
Second Decision	2024-08-01 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-01 07:59
Articles in Press	2024-08-01 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-21 02:35
Publish the Manuscript Online	2024-09-09 08:41

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Senegenin suppresses hepatocellular carcinoma by regulating O-GlcNAcylation
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang Zhang, Li-Qiong Wang and Zhi-Yong Liu
ORCID	Author(s) ORCID Number Zhi-Yong Liu http://orcid.org/0009-0007-2757-6885
Funding Agency and Grant Number
Corresponding Author	Zhi-Yong Liu, MD, Associate Chief Physician, Department of Traditional Chinese Medicine, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Park Road East, Qingpu District, Shanghai 201700, China. lzhy780404@163.com
Key Words	Senegenin; O-GlcNAcylation; Liver cancer; Pathogenesis; Metastasis
Core Tip	This study investigated the effects of senegenin and O-GlcNAcylation on the growth and metastasis of hepatocellular carcinoma (HCC) cells. The findings indicated that O-GlcNAcylation levels are elevated in HCC tissues and cells, and senegenin can reduce these levels by targeting proteins involved in nuclear factor-kappa B (NF-κB) and c-Jun N-terminal kinase (JNK) signaling pathways. This modulation decreases the levels of O-linked N-acetylglucosamine transferase and inhibits the proliferation and metastasis of HCC cells, providing new therapeutic targets for liver cancer.
Publish Date	2024-09-09 08:41
Citation	<p>Zhang X, Wang LQ, Liu ZY. Senegenin suppresses hepatocellular carcinoma by regulating O-GlcNAcylation. <i>World J Gastrointest Oncol</i> 2024; 16(9): 3994-4005</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i9/3994.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i9.3994

Full Article (PDF)	WJGO-16-3994-with-cover.pdf
Manuscript File	96680_Auto_Edited_054027.docx
Answering Reviewers	96680-answering-reviewers.pdf
Audio Core Tip	96680-audio.mp3
Biostatistics Review Certificate	96680-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96680-conflict-of-interest-statement.pdf
Copyright License Agreement	96680-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	96680-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	96680-non-native-speakers.pdf
Peer-review Report	96680-peer-reviews.pdf
Scientific Misconduct Check	96680-scientific-misconduct-check.png
Scientific Editor Work List	96680-scientific-editor-work-list.pdf
CrossCheck Report	96680-crosscheck-report.png
CrossCheck Report	96680-crosscheck-report.pdf