| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Yun Lin, Hou Huang, Jin-Jie Yu, Feng Su, Tian Jiang, Shao-Yuan Zhang, Lu Lv, Tao Long, Hui-Wen Pan, Jun-Qing Qi, Qiang Zhou, Wei-Feng Tang, Guo-Wen Ding, Li-Ming Wang, Li-Jie Tan and Jun Yin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Natural Science Foundation of China |
82350127, 82241013 |
| the Shanghai Natural Science Foundation |
20ZR1411600 |
| the Shanghai Shenkang Hospital Development Center |
SHDC2020CR4039 |
| the Bethune Ethicon Excellent Surgery Foundation |
CESS2021TC04 |
| Xuhui District Medical Research Project of Shanghai |
SHXH201805 |
|
| Corresponding Author |
Jun Yin, PhD, Professor, Department of Thoracic Surgery, Zhongshan Hospital Affiliated to Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. jun_yin@fudan.edu.cn |
| Key Words |
Activin A receptor type 1C; Single nucleotide polymorphisms; Esophageal squamous cell carcinoma; Genetic susceptibility; Hospital-based cohort study |
| Core Tip |
In this study, a case-control approach was used to investigate the association between specific single nucleotide polymorphisms (SNPs) of the ACVR1C gene and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. The study included 2186 participants, comprising 1043 ESCC patients and 1143 healthy controls. Notably, the rs4556933 G>A SNP was significantly associated with ESCC risk across several genetic models. Stratified analysis indicated an increased risk in older males and smokers. These findings suggest that ACVR1C SNPs play a critical role in ESCC susceptibility, meriting further investigation into their involvement in cancer development. |
| Publish Date |
2024-12-12 09:30 |
| Citation |
<p>Lin SY, Huang H, Yu JJ, Su F, Jiang T, Zhang SY, Lv L, Long T, Pan HW, Qi JQ, Zhou Q, Tang WF, Ding GW, Wang LM, Tan LJ, Yin J. Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population. <i>World J Gastrointest Oncol</i> 2025; 17(1): 96702</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i1/96702.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i1.96702 |
