| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Marina Ribeiro Paulini, Letícia Ferreira Montarele, Dimitrius Leonardo Pitol, Gisele Giannocco, Bruno Fiorelini Pereira, Daniela Vieira Buchaim, Carlos Henrique Bertoni Reis, Rogério Leone Buchaim and Joao Paulo Mardegan Issa |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FAPESP |
2019/03699-1 |
|
| Corresponding Author |
Joao Paulo Mardegan Issa, PhD, Professor, Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Ave Cafe S-N, Ribeirao Preto 14040-904, Brazil. jpmissa@forp.usp.br |
| Key Words |
Bone repair; Melatonin; Gene expression; Rhbmp-2; Scaffold; Tissue engineering; Guided bone regeneration |
| Core Tip |
Melatonin is believed to be an important endogenous biological factor for bone remodeling. Furthermore, growth factors such as bone morphogenetic proteins (rhBMPs) have been used to repair bone defects. The aim of this study was to assess the expression of cytokine genes (IL-1β, IL-6, IL-10 and TNF-α), markers of osteoclastogenesis (RANK, RANKL and OPG) and MMPs (MMP-1, MMP-2, MMP-8 and MMP-13) from the treatment of melatonin associated with an osteogenic membrane and rhBMP-2 on the recovery of a bone injury. |
| Publish Date |
2024-11-15 09:06 |
| Citation |
<p>Paulini MR, Montarele LF, Pitol DL, Giannocco G, Pereira BF, Buchaim DV, Reis CHB, Buchaim RL, Mardegan Issa JP. Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling. <i>World J Orthop</i> 2024; 15(11): 1075-1087</p> |
| URL |
https://www.wjgnet.com/2218-5836/full/v15/i11/1075.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v15.i11.1075 |
