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Articles Published Processes
12/13/2024 3:22:39 AM | Browse: 207 | Download: 848
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Received |
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2024-05-14 08:23 |
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Peer-Review Started |
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2024-05-14 08:23 |
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First Decision by Editorial Office Director |
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2024-07-30 06:46 |
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Return for Revision |
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2024-07-30 06:46 |
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Revised |
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2024-09-16 09:09 |
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Publication Fee Transferred |
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2024-11-12 14:09 |
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Second Decision by Editor |
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2024-10-31 23:19 |
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Second Decision by Editor-in-Chief |
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2024-11-03 05:00 |
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Final Decision by Editorial Office Director |
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2024-11-12 08:12 |
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Articles in Press |
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2024-11-12 08:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-12-09 02:09 |
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Publish the Manuscript Online |
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2024-12-13 03:22 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ji-Gang He, Xin-Xin Wu, Si Li, Dan Yan, Gao-Peng Xiao and Fu-Gang Mao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82060299 |
| Medical Discipline Leader Project of Yunnan Provincial Health Commission |
D-2019020 |
| Yunnan Provincial Government Ten Thousand Person-Top Young Talents Project |
KH-SWR-QNBJ-2019-002 |
| Clinical Medical Center of the First People’s Hospital of Yunnan Province |
2021LCZXXF-XZ04, 2022LCZXKF-HX05 |
| Kunming Medical Joint Special Project - Outstanding Youth Cultivation Project |
202101AY070001-034 |
| Kunming Medical Joint Special Project |
202101AY070001-272 |
| Famous Doctor Project of “Xingdian Talent Support Plan” of Yunnan Province |
XDYC-MY-2022-0037 |
| Yunnan Province 2023 Undergraduate Education and Teaching Reform Research Project |
2023BKXJJG-F04002 |
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| Corresponding Author |
Fu-Gang Mao, MD, Professor, Department of Ultrasonic, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. maofugang666@163.com |
| Key Words |
Bone marrow mesenchymal stem cells; Exosomes; MicroRNA-540-3p; Cardiac allograft; Immune tolerance |
| Core Tip |
This study explores the innovative use of exosomes from bone marrow mesenchymal stem cells overexpressing microRNA-540-3p to promote immune tolerance in heart transplantation. Demonstrating a significant modulation of the CD74/nuclear factor-kappaB pathway, these exosomes enhance graft survival and function by altering dendritic and T cell responses. Our findings suggest a promising therapeutic strategy that reduces the need for prolonged immunosuppression, offering a substantial advancement in transplant medicine. This approach underscores the potential of targeted exosomal therapies in improving outcomes for heart transplant patients. |
| Publish Date |
2024-12-13 03:22 |
| Citation |
He JG, Wu XX, Li S, Yan D, Xiao GP, Mao FG. Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft. World J Stem Cells 2024; 16(12): 1022-1046 |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i12/1022.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i12.1022 |
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