Publication Name	World Journal of Stem Cells
Manuscript ID	96726
Country	China

Received	2024-05-14 08:23
Peer-Review Started	2024-05-14 08:23
To Make the First Decision
Return for Revision	2024-07-30 06:46
Revised	2024-09-16 09:09
Second Decision	2024-10-31 23:19
Accepted by Journal Editor-in-Chief	2024-11-03 05:00
Accepted by Executive Editor-in-Chief	2024-11-12 08:12
Articles in Press	2024-11-12 08:12
Publication Fee Transferred	2024-11-12 14:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-09 02:09
Publish the Manuscript Online	2024-12-13 03:22

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft
Manuscript Source	Unsolicited Manuscript
All Author List	Ji-Gang He, Xin-Xin Wu, Si Li, Dan Yan, Gao-Peng Xiao and Fu-Gang Mao
ORCID	Author(s) ORCID Number Fu-Gang Mao http://orcid.org/0009-0007-7625-839X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82060299 Medical Discipline Leader Project of Yunnan Provincial Health Commission D-2019020 Yunnan Provincial Government Ten Thousand Person-Top Young Talents Project KH-SWR-QNBJ-2019-002 Clinical Medical Center of the First People’s Hospital of Yunnan Province 2021LCZXXF-XZ04, 2022LCZXKF-HX05 Kunming Medical Joint Special Project - Outstanding Youth Cultivation Project 202101AY070001-034 Kunming Medical Joint Special Project 202101AY070001-272 Famous Doctor Project of “Xingdian Talent Support Plan” of Yunnan Province XDYC-MY-2022-0037 Yunnan Province 2023 Undergraduate Education and Teaching Reform Research Project 2023BKXJJG-F04002
Corresponding Author	Fu-Gang Mao, MD, Professor, Department of Ultrasonic, The First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. maofugang666@163.com
Key Words	Bone marrow mesenchymal stem cells; Exosomes; MicroRNA-540-3p; Cardiac allograft; Immune tolerance
Core Tip	This study explores the innovative use of exosomes from bone marrow mesenchymal stem cells overexpressing microRNA-540-3p to promote immune tolerance in heart transplantation. Demonstrating a significant modulation of the CD74/nuclear factor-kappaB pathway, these exosomes enhance graft survival and function by altering dendritic and T cell responses. Our findings suggest a promising therapeutic strategy that reduces the need for prolonged immunosuppression, offering a substantial advancement in transplant medicine. This approach underscores the potential of targeted exosomal therapies in improving outcomes for heart transplant patients.
Publish Date	2024-12-13 03:22
Citation	<p>He JG, Wu XX, Li S, Yan D, Xiao GP, Mao FG. Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft. <i>World J Stem Cells</i> 2024; 16(12): 1022-1046</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i12/1022.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i12.1022

Full Article (PDF)	WJSC-16-1022-with-cover.pdf
The ARRIVE Guidelines	96726-The-ARRIVE-Guidelines.pdf
Manuscript File	96726_Auto_Edited_112900.docx
Answering Reviewers	96726-answering-reviewers.pdf
Audio Core Tip	96726-audio.m4a
Biostatistics Review Certificate	96726-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96726-conflict-of-interest-statement.pdf
Copyright License Agreement	96726-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96726-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	96726-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	96726-non-native-speakers.pdf
Supplementary Material	96726-supplementary-material.pdf
Peer-review Report	96726-peer-reviews.pdf
Journal Editor-in-Chief Review Report	96726-journal-editor-in-chief.pdf
Scientific Misconduct Check	96726-scientific-misconduct-check.png
Scientific Editor Work List	96726-scientific-editor-work-list.pdf
CrossCheck Report	96726-crosscheck-report.pdf