Publication Name	World Journal of Diabetes
Manuscript ID	96749
Country	China

Received	2024-05-14 18:53
Peer-Review Started	2024-05-14 12:32
To Make the First Decision
Return for Revision	2024-07-23 04:39
Revised	2024-08-10 13:29
Second Decision	2024-08-30 12:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-06 08:33
Articles in Press	2024-09-06 08:33
Publication Fee Transferred	2024-09-07 05:22
Edit the Manuscript by Language Editor	2024-09-13 02:04
Typeset the Manuscript	2024-09-18 07:32
Publish the Manuscript Online	2024-09-26 08:51

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Combining GLP-1 receptor agonists and SGLT-2 inhibitors for cardiovascular disease prevention: A systematic review with multiple network meta-regressions
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Jing Zhu, John P H Wilding and Xiao-Song Gu
ORCID	Author(s) ORCID Number Jing-Jing Zhu http://orcid.org/0000-0002-9762-8480 John P H Wilding http://orcid.org/0000-0003-2839-8404 Xiao-Song Gu http://orcid.org/0000-0002-5553-4785
Funding Agency and Grant Number	Funding Agency Grant Number China Scholarship Council 202006920018 Key Talent Program for Medical Applications of Nuclear Technology XKTJ-HRC2021007 the Second Affiliated Hospital of Soochow University SDFEYBS1815 National Natural Science Foundation of China 82170831 The Jiangsu Innovation & Career Fund for PhD 2019
Corresponding Author	Xiao-Song Gu, MD, PhD, Chief Physician, Full Professor, Cardiovascular Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, China. xiaosonggu@suda.edu.cn
Key Words	Type 2 diabetes; Glucagon-like peptide-1 receptor agonist; Sodium-glucose co-transporter-2 inhibitor; Combination treatment; Cardiovascular outcome; Systematic review; Network meta-regression
Core Tip	Major cardiovascular outcome trials suggest that patients with prior cardiovascular co-morbidities may not gain sufficient cardiovascular protection from glucagon-like peptide-1 receptor agonists (GLP-1RA) or sodium-glucose co-transporter-2 inhibitors (SGLT-2I) alone. This systematic review with network meta-regression demonstrated that the combination treatment may provide greater cardiovascular benefit compared with GLP-1RA or SGLT-2I alone. In patients with prior myocardial infarction or heart failure, the monotherapy may not be associated with consistently improved cardiovascular outcomes, hence the combination treatment might be considered for cardiovascular disease prevention.
Publish Date	2024-09-26 08:51
Citation	<p>Zhu JJ, Wilding JPH, Gu XS. Combining GLP-1 receptor agonists and SGLT-2 inhibitors for cardiovascular disease prevention: A systematic review with multiple network meta-regressions. <i>World J Diabetes</i> 2024; 15(10): 2135-2146</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i10/2135.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i10.2135

Full Article (PDF)	WJD-15-2135-with-cover.pdf
PRISMA 2009 Checklist	96749-PRISMA-2009-Checklist.pdf
Manuscript File	96749_Auto_Edited_090126.docx
Answering Reviewers	96749-answering-reviewers.pdf
Audio Core Tip	96749-audio.mp3
Biostatistics Review Certificate	96749-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96749-conflict-of-interest-statement.pdf
Copyright License Agreement	96749-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96749-foundation-statement.pdf
Supplementary Material	96749-supplementary-material.pdf
Peer-review Report	96749-peer-reviews.pdf
Journal Editor-in-Chief Review Report	96749-journal-editor-in-chief.pdf
Scientific Misconduct Check	96749-scientific-misconduct-check.png
Scientific Editor Work List	96749-scientific-editor-work-list.pdf
CrossCheck Report	96749-crosscheck-report.png
CrossCheck Report	96749-crosscheck-report.pdf