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Articles Published Processes
12/12/2024 9:30:50 AM | Browse: 140 | Download: 674
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Received |
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2024-05-15 18:16 |
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Peer-Review Started |
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2024-05-15 18:16 |
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First Decision by Editorial Office Director |
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2024-08-03 03:31 |
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Return for Revision |
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2024-08-03 03:31 |
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Revised |
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2024-08-14 17:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-08-28 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-08-28 07:30 |
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Articles in Press |
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2024-08-28 07:30 |
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Edit the Manuscript by Language Editor |
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2024-09-21 20:53 |
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Typeset the Manuscript |
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2024-09-27 02:01 |
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Publish the Manuscript Online |
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2024-12-12 09:30 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Dihydropyrimidine-dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: An Italian single institution experience
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mariarosaria D'Amato, Gennaro Iengo, Nicola Massa and Chiara Carlomagno |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mariarosaria D'Amato, MD, Doctor, Doctor, Department of Oncology, Ospedale San Rocco ASL Caserta, Via XXI Luglio, Sessa Aurunca 81037, Campania, Italy. mariar.damato@gmail.com |
| Key Words |
Dihydropyrimidine dehydrogenase; DPYD polymorphisms; Fluoropyrimidine; Caucasic population; Gastrointestinal cancers |
| Core Tip |
In this retrospective study, we report the prevalence of DPYD polymorphisms in a real-world population of patients treated for gastrointestinal malignancies and their impact on fluoropyrimidine tolerability. Furthermore, we demonstrate that the presence of DPYD polymorphisms leads to an increased risk of G3-G4 non-hematologic toxicity and more frequent dose reductions, while we did not find a significant difference in chemotherapy delay. |
| Publish Date |
2024-12-12 09:30 |
| Citation |
D'Amato M, Iengo G, Massa N, Carlomagno C. Dihydropyrimidine-dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: An Italian single institution experience. World J Gastrointest Oncol 2025; 17(1): 96822 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i1/96822.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i1.96822 |
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