| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ashraf Ali, Hany Abdel-Hafiz, Mohd Suhail, Amany Al-Mars, Mohammad Khalid Zakaria, Kaneez Fatima, Sultan Ahmad, Esam Azhar, Adeel Chaudhary and Ishtiaq Qadri |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ishtiaq Qadri, PhD, Professor, Head Medical Biotechnology, Head Liver Biology, Head Translational Research, Department of Medical Biotechnology, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216, Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com |
| Key Words |
Hepatitis B virus; Hepatocellular carcinoma; Transcription factors; Apoptosis; Epigenetics; Mutants; Tumor necrosis factor; Activating protein; Transforming growth factor; Mitogen activated protein kinase |
| Core Tip |
The available evidence supports a well-defined for the hepatitis B virus-encoded X protein (HBx) protein in viral-induced hepatocellular carcinoma. The progression cell cycle, transactivation potential, compromised DNA repair, inhibition the tumor suppressor gene and senescence-related factors are few of the key pathways by which HBx is known to promote pathogenesis. The activation and inhibition of cellular calcium and tyrosine kinase signaling pathways are some of the other pathways modulated by HBx expression. Individually charged amino acids (K-130, V-131, D-120, 121) and or steches of amino acids (132-140) present in the carboxy-terminus of HBx protein seems to enhance the protein’s ability to deregulates cellular processes. |
| Publish Date |
2014-08-18 16:49 |
| Citation |
Ali A, Abdel-Hafiz H, Suhail M, Al-Mars A, Zakaria MK, Fatima K, Ahmad S, Azhar E, Chaudhary A, Qadri I. Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma. World J Gastroenterol 2014; 20(30): 10238-10248 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i30/10238.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i30.10238 |
