| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Naoki Adachi, Tadahiro Numakawa, Misty Richards, Shingo Nakajima and Hiroshi Kunugi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health and Labor Sciences Research Grants (Comprehensive Research on Disability, Health, and Welfare H21-kokoro-002) (H. K.) |
|
| Core Research for Evolutional Science and Technology Program, CREST, Japan Science and Technology Agency (JST) (T.N., N.A. and H.K.) |
|
| Naito Foundation (N.A) |
|
| Takeda Science Foundation (T. N.) |
|
| Scientific Research (B), (JSPS KAKENHI) (T. N.) |
24300139 |
| Grant-in-Aid for Challenging Exploratory Research (JSPS KAKENHI) (T. N.) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan |
25640019 |
|
| Corresponding Author |
Tadahiro Numakawa, PhD, Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. numakawa@ncnp.go.jp
|
| Key Words |
Brain-derived neurotrophic factor; Transcription; Transport; Secretion; Neurodegenerative disorders; Psychiatric disorders |
| Core Tip |
Brain-derived neurotrophic factor (BDNF) plays essential roles in the central nervous system (CNS) through a specific tropomyosin-related kinase receptor B (TrkB), contributing to neuronal survival, neurite outgrowth, and synaptic function. It is critically required for normal development and functions of the brain. A number of reports have shown an importance of BDNF in the pathophysiology of brain-associated diseases. This review describes molecular mechanisms underlying gene expression, transport, and secretion of BDNF and its function in the CNS. We further introduce recent findings on the possible involvement of BDNF in the pathophysiology of neurodegenerative and psychiatric diseases, and the potential effectiveness of enhancing BDNF/TrkB system for therapeutic applications.
|
| Publish Date |
2014-12-02 12:16 |
| Citation |
Adachi N, Numakawa T, Richards M, Nakajima S, Kunugi H. New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases. World J Biol Chem 2014; 5(4): 409-428 |
| URL |
http://www.wjgnet.com/1949-8454/full/v5/i4/409.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v5.i4.409 |
