Publication Name	World Journal of Stem Cells
Manuscript ID	96893
Country	China

Received	2024-05-17 09:37
Peer-Review Started	2024-05-17 09:37
To Make the First Decision
Return for Revision	2024-11-11 08:27
Revised	2024-11-19 14:08
Second Decision	2025-01-15 02:42
Accepted by Journal Editor-in-Chief	2025-01-15 11:16
Accepted by Executive Editor-in-Chief	2025-01-16 07:10
Articles in Press	2025-01-16 07:10
Publication Fee Transferred	2024-11-23 15:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-25 03:23
Publish the Manuscript Online	2025-02-24 05:39

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Basic Study
Article Title	Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Xia, Kun Zhou, Lin-Ying An, Min Zhao, Bin-Le Tian, Jin-Yan Zhao, Zhi-Gang Zhou and Yin Tong
ORCID	Author(s) ORCID Number Jin-Yan Zhao http://orcid.org/0000-0002-6403-5857 Yin Tong http://orcid.org/0000-0001-7551-5509
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Natural Science Foundation 21ZR1452300 Clinical Research Innovation Plan of Shanghai General Hospital CCTR-2022B04
Corresponding Author	Yin Tong, PhD, Professor, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China. 18616909158@163.com
Key Words	Sepsis; Bone mesenchymal stem cells; Hematopoietic stem cells; Senescence; Nicotinamide adenine dinucleotide
Core Tip	Sepsis often leads to multiorgan dysfunction, including damage to bone marrow mesenchymal stem cells (BMSCs). This damage accelerates the aging of BMSCs, resulting in impaired self-renewal and differentiation abilities and weakened hematopoietic support functions. These changes disrupt hematopoiesis and may even cause long-term immunosuppression and bone loss. Nicotinamide adenine dinucleotide, which protects mitochondrial function, can rejuvenate septic BMSCs and provide a new target for adjunctive therapy to control post-sepsis complications.
Publish Date	2025-02-24 05:39
Citation	<p>Xia X, Zhou K, An LY, Zhao M, Tian BL, Zhao JY, Zhou ZG, Tong Y. Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells. <i>World J Stem Cells</i> 2025; 17(2): 96893</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i2/96893.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i2.96893

Full Article (PDF)	WJSC-17-96893-with-cover.pdf
Manuscript File	96893_Auto_Edited_085201.docx
Answering Reviewers	96893-answering-reviewers.pdf
Audio Core Tip	96893-audio.mp3
Biostatistics Review Certificate	96893-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	96893-conflict-of-interest-statement.pdf
Copyright License Agreement	96893-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	96893-foundation-statement.pdf
Institutional Review Board Approval Form or Document	96893-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	96893-non-native-speakers.pdf
Supplementary Material	96893-supplementary-material.pdf
Peer-review Report	96893-peer-reviews.pdf
Journal Editor-in-Chief Review Report	96893-journal-editor-in-chief.pdf
Scientific Misconduct Check	96893-scientific-misconduct-check.png
Scientific Editor Work List	96893-scientific-editor-work-list.pdf
CrossCheck Report	96893-crosscheck-report.pdf