Publication Name	World Journal of Psychiatry
Manuscript ID	97046
Country	China

Received	2024-05-21 07:35
Peer-Review Started	2024-05-23 02:05
To Make the First Decision
Return for Revision	2024-07-19 03:04
Revised	2024-08-09 05:51
Second Decision	2024-08-20 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-20 07:47
Articles in Press	2024-08-20 07:47
Publication Fee Transferred	2024-08-23 08:31
Edit the Manuscript by Language Editor	2024-08-29 08:44
Typeset the Manuscript	2024-09-04 03:44
Publish the Manuscript Online	2024-09-11 07:02

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Retrospective Cohort Study
Article Title	Predictive effect of lipopolysaccharide-stimulated inflammatory cytokines on symptoms of generalized anxiety disorder
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Yuan Wang, Na Liu, Xiao-Xiao Qi, Bing Han, Jing-Na Sun, Zheng-Li Chen, Ming-Wei Wang and Yan-Yong Wang
ORCID	Author(s) ORCID Number Yan-Yong Wang http://orcid.org/0009-0003-2435-0128
Funding Agency and Grant Number	Funding Agency Grant Number The 2023 Scientific Research Fund Project of Hebei Provincial Health and Family Planning Commission No. 20231081 The "Spark" Youth Research Project, The First Hospital of Hebei Medical University No. XH202302
Corresponding Author	Yan-Yong Wang, MD, Chief Doctor, Department of Neurology, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang 050000, Hebei Province, China. 57600267@hebmu.edu.cn
Key Words	Lipopolysaccharide; Cytokine; Generalized anxiety disorder; Inflammatory cytokines; Anxiety
Core Tip	In this study, the physical symptoms of generalized anxiety disorder (GAD) were found to be related to inflammatory factors and the innate ability to produce inflammation in vivo. Interleukin (IL)-1β, IL-8, IL-10 and tumor necrosis factor-α can be used as predictors of physical or mental anxiety in patients with GAD. This study provides evidence that can be used to monitor the mental state of patients through lipopolysaccharide-induced inflammatory cytokines. The design of strategies for generalized anxiety disorder that can benefit from personalized treatment with anti-inflammatory drugs may be promising.
Publish Date	2024-09-11 07:02
Citation	<p>Wang WY, Liu N, Qi XX, Han B, Sun JN, Chen ZL, Wang MW, Wang YY. Predictive effect of lipopolysaccharide-stimulated inflammatory cytokines on symptoms of generalized anxiety disorder. <i>World J Psychiatry</i> 2024; 14(9): 1308-1318</p>
URL	https://www.wjgnet.com/2220-3206/full/v14/i9/1308.htm
DOI	https://dx.doi.org/10.5498/wjp.v14.i9.1308

Full Article (PDF)	WJP-14-1308-with-cover.pdf
STROBE Statement	97046-STROBE-statement.pdf
Manuscript File	97046_Auto_Edited_021839.docx
Answering Reviewers	97046-answering-reviewers.pdf
Audio Core Tip	97046-audio.mp3
Biostatistics Review Certificate	97046-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97046-conflict-of-interest-statement.pdf
Copyright License Agreement	97046-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97046-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	97046-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	97046-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	97046-non-native-speakers.pdf
Peer-review Report	97046-peer-reviews.pdf
Scientific Misconduct Check	97046-scientific-misconduct-check.png
Scientific Editor Work List	97046-scientific-editor-work-list.pdf
CrossCheck Report	97046-crosscheck-report.pdf