Publication Name	World Journal of Clinical Oncology
Manuscript ID	97052
Country	India

Received	2024-05-21 09:47
Peer-Review Started	2024-05-21 09:47
To Make the First Decision
Return for Revision	2024-09-08 09:42
Revised	2024-09-21 10:32
Second Decision	2024-10-08 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 08:11
Articles in Press	2024-10-08 08:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-16 02:27
Publish the Manuscript Online	2024-10-22 08:28

ISSN	2218-4333 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Chronic pancreatitis as a driving factor for pancreatic cancer: An epidemiological understanding
Manuscript Source	Invited Manuscript
All Author List	Amlan Das, Akash Bararia, Sanghamitra Mukherjee and Nilabja Sikdar
ORCID	Author(s) ORCID Number Amlan Das http://orcid.org/0000-0002-9295-3743 Akash Bararia http://orcid.org/0000-0002-9069-3116 Nilabja Sikdar http://orcid.org/0000-0003-4465-472X
Funding Agency and Grant Number	Funding Agency Grant Number The Department of Biotechnology, Government of India Grant Sanction No. RLS/BT/Re-entry/05/2012
Corresponding Author	Nilabja Sikdar, PhD, Research Scientist, Human Genetics Unit, Indian Statistical Institute, No. 203 Plot, Barrackpore Trunk Road, Dunlop, Bonhooghly Government Colony, Kolkata 700108, India. snilabja@gmail.com
Key Words	Pancreatic ductal adenocarcinoma; Chronic pancreatitis; Acute pancreatitis; Epidemiological study, Pancreatic cancer
Core Tip	The United States has a high incidence of pancreatic cancer (PanCa) cases that result from chronic pancreatitis (CP). This link between diseases is well-established in many scientific studies and clinical practices. In CP, the chronic inflammation of the pancreas causes DNA mutations and cellular changes that may make one prone to cancerous tumors. The CP is responsible for the persistent damage and fibrosis as a consequence of continuous inflammation of the organ over time. Such chronic inflammation promotes DNA mutations and oxidative stress, and damages cells thus leading to an increased risk of carcinogenesis. On a long-term basis, these alterations can cause the development of pancreatic intraepithelial neoplasia, a precancerous stage prior to pancreatic ductal adenocarcinoma (PDAC), which is another name for PDAC; it’s also regarded as the most prevalent type of this ailment. An example is that hereditary pancreatitis patients have up to 40% lifetime risk by age 70 years. Non-genetic CP also increases risks, although not very greatly. Development of PanCa is partly associated with CP risk factors like genetic mutations such as protease serine 1, serine protease inhibitor kazal type 1, cystic fibrosis transmembrane conductance regulator, heavy alcohol use, and smoking.
Publish Date	2024-10-22 08:28
Citation	<p>Das A, Bararia A, Mukherjee S, Sikdar N. Chronic pancreatitis as a driving factor for pancreatic cancer: An epidemiological understanding. <i>World J Clin Oncol</i> 2024; 15(12): 1459-1462</p>
URL	https://www.wjgnet.com/2218-4333/full/v15/i12/1459.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i12.1459

Full Article (PDF)	WJCO-15-1459-with-cover.pdf
Manuscript File	97052_Auto_Edited_040808.docx
Answering Reviewers	97052-answering-reviewers.pdf
Audio Core Tip	97052-audio.m4a
Conflict-of-Interest Disclosure Form	97052-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	97052-non-native-speakers.pdf
Peer-review Report	97052-peer-reviews.pdf
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Scientific Editor Work List	97052-scientific-editor-work-list.pdf
CrossCheck Report	97052-crosscheck-report.pdf