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Articles Published Processes
5/21/2015 1:54:00 PM | Browse: 1112 | Download: 1041
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Received |
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2014-02-25 10:11 |
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Peer-Review Started |
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2014-02-26 09:07 |
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To Make the First Decision |
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2014-03-26 15:26 |
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Return for Revision |
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2014-04-02 20:49 |
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Revised |
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2014-05-28 00:00 |
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Second Decision |
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2015-02-27 09:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-03-09 17:12 |
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Articles in Press |
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2015-03-09 17:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-05-04 13:50 |
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Publish the Manuscript Online |
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2015-05-21 13:54 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Recent advances in the diagnosis and treatment of acute myocardial infarction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Koushik Reddy, Asma Khaliq and Robert J Henning |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research facilities at the James A Haley VA Hospital(In part) |
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| Florida King Biomedical Research Program |
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| Muscular Dystrophy Association |
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| Robert O Law Foundation |
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| Cornelius Foundation |
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| Corresponding Author |
Robert J Henning, MD, Department of Medicine, James A Haley Veterans Administration Hospital and the University of South Florida College of Medicine, 13000 Bruce B Downs Blvd, Tampa, FL 33612,
United States. robert.henning@va.gov |
| Key Words |
Myocardial necrosis; Type 1-5 myocardial infarctions; Troponin assays; Percutaneous coronary intervention; Fibrinolytic therapy; Thienopyridines; Cardioprotection; Bone marrow stem cells; Cardiac stem cells |
| Core Tip |
The Third Universal Definition of myocardial infarction (MI) combines clinical symptoms, cardiac biomarkers and electrocardiogram (ECG) changes. Small amounts of myocardial necrosis may occur with heart failure, renal failure, myocarditis, arrhythmias, pulmonary embolism or uneventful percutaneous or surgical coronary revascularization and should be termed myocardial injury. High sensitivity troponin assays increase the sen sitivity but decrease the specificity of MI diagnosis. The ECG remains a cornerstone of MI diagnosis. Primary percutaneous coronary intervention in a timely manner is the primary treatment of patients with acute ST segment elevation MI. Antiplatelet agents (clopidogrel, prasugrel or ticagrelor), in addition to aspirin, reduce patient MI morbidity and mortality. The recent LateTime, Time, and Swiss Multicenter Trials of bone marrow stem cells in MI treatment did not demonstrate significant improvement in patient LV ejection fraction in comparison with placebo. In contrast, cardiac stem cells from the right atrial appen dage or ventricular septum/apex in the SCIPIO and CADUCEUS Trials reduced patient MI size and increased viable myocardium. Studies with cardiac stem cells are continuing. |
| Publish Date |
2015-05-21 13:54 |
| Citation |
Reddy K, Khaliq A, Henning RJ. Recent advances in the diagnosis and treatment of acute myocardial infarction. World J Cardiol 2015; 7(5): 243-276 |
| URL |
http://www.wjgnet.com/1949-8462/full/v7/i5/243.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v7.i5.243 |
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