| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Decreased gene expression of IL-2 receptor subunit γ (CD132) in tissues of Crohn’s disease patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Juan Carlos Andreu-Ballester, Carolina Hurtado-Marcos, Carlos García-Ballesteros, Jaime Pérez-Griera, Fernando Izquierdo, Dolores Ollero, Ana Jiménez, Rafael Gil-Borrás, Antonio Llombart-Cussac, Francisca López-Chuliá and Carmen Cuéllar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Juan Carlos Andreu-Ballester, MD, PhD, Department of Research, Fisabio Foundation, Av de Cataluña 21, Valencia 46020, Spain. jcandreuballester@outlook.com |
| Key Words |
Crohn’s disease; Interleukin-7 gene expression; Interleukin-2 receptor subunit γ (CD 132); Caspase 3; γδ T cells |
| Core Tip |
Andreu-Ballester JC, Hurtado-Marcos C, Garcia-Ballesteros C, Pérez-Griera J, Izquierdo F, Ollero D, Jiménez A, Gil-Borrás R, Llombart-Cussac A, Lopez-Chulia F, Cuéllar C. Decreased gene expression of IL-2 receptor subunit γ (CD132) in tissues of Crohn’s disease patients.. World J Gastroenterol 2024; In press Core Tip: A deficiency in T cells, and specifically in γδ T cells, has been described in Crohn's disease. Interleukin 7 is essential for the activation and proliferation of this lymphocyte’s subsets. This work demonstrates a decrease in IL-2 receptor subunit γ (CD132) in tissues of Crohn's disease patients. This could be related to the deficiency of γδ T cells, and could open new works and lines of research for the application of new therapies against this disease. |
| Publish Date |
2025-03-26 08:40 |
| Citation |
<p>Andreu-Ballester JC, Hurtado-Marcos C, García-Ballesteros C, Pérez-Griera J, Izquierdo F, Ollero D, Jiménez A, Gil-Borrás R, Llombart-Cussac A, López-Chuliá F, Cuéllar C. Decreased gene expression of IL-2 receptor subunit γ (CD132) in tissues of Crohn’s disease patients. <i>World J Gastroenterol</i> 2025; 31(12): 97120</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i12/97120.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i12.97120 |
