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Articles Published Processes
8/12/2024 8:42:28 AM | Browse: 82 | Download: 292
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Received |
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2024-06-13 10:58 |
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Peer-Review Started |
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2024-06-13 10:58 |
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To Make the First Decision |
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Return for Revision |
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2024-07-03 05:57 |
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Revised |
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2024-07-05 02:59 |
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Second Decision |
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2024-07-11 02:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-07-11 07:49 |
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Articles in Press |
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2024-07-11 07:49 |
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Publication Fee Transferred |
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2024-07-16 07:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-07-20 23:50 |
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Publish the Manuscript Online |
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2024-08-12 08:42 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Mei Yu, Gui-Hong Jin, Chong Zhong, Hao Qian, Lei Wang and Feng Zhan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Feng Zhan, MMed, Associate Chief Physician, Department of Pediatrics, The First People's Hospital of Chuzhou, No. 369 Zuiweng West Road, Nanqiao District, Chuzhou 239001, Anhui Province, China. zf23260523@163.com |
| Key Words |
Epilepsy; Interleukin-6 receptor blockade; Mendelian randomization; Neuroinflammation; Psychiatric disorders |
| Core Tip |
This study employed mendelian randomization to explore the potential neuroprotective role of interleukin (IL)-6 receptor (IL6R) blockade in epilepsy, highlighting how it may decrease the incidence of epilepsy by addressing neuro-inflammatory and possibly non-inflammatory pathways. While the results shown a modest reduction in epilepsy risk, they vary across epileptic subtypes and suggested complex interactions with neuropsychiatric conditions. The findings underscored the necessity for further comprehensive investigations to understand the multifaceted effects of IL-6 signaling on both epilepsy and related psychiatric disorders, potentially paving the way for innovative therapeutic strategies that encompass neurological and psychiatric care in epilepsy management. |
| Publish Date |
2024-08-12 08:42 |
| Citation |
<p>Yu YM, Jin GH, Zhong C, Qian H, Wang L, Zhan F. Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study. <i>World J Psychiatry</i> 2024; 14(8): 1244-1253</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v14/i8/1244.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v14.i8.1244 |
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