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Articles Published Processes
12/27/2024 1:37:16 PM | Browse: 187 | Download: 987
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Received |
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2024-05-24 02:34 |
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Peer-Review Started |
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2024-05-24 02:36 |
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First Decision by Editorial Office Director |
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2024-09-23 07:57 |
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Return for Revision |
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2024-09-23 07:57 |
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Revised |
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2024-10-10 08:51 |
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Publication Fee Transferred |
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2024-11-29 07:30 |
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Second Decision by Editor |
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2024-11-22 03:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-22 11:07 |
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Articles in Press |
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2024-11-22 11:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-12-06 07:21 |
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Publish the Manuscript Online |
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2024-12-27 13:37 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Synergistic inhibition of colorectal cancer progression by silencing Aurora A and the targeting protein for Xklp2
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gui-Xian Sheng, Yu-Jia Zhang and Tao Shang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tao Shang, Department of Colorectal Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), No. 54 Youdian Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. shangtaomail@163.com |
| Key Words |
Aurora kinase A; Targeting protein for Xklp2; Microtubule nucleation factor; Colorectal cancer; Proliferation; Migration; Invasion |
| Core Tip |
In this study, we evaluated three gene datasets and identified 13 crucial genes. Results from SW480 and LOVO cells showed that Aurora kinase A (AURKA) and the targeting protein for Xklp2 (TPX2) blocked cell cycle progression and promoted cell apoptosis of colorectal cancer (CRC). Knockdown of either AURKA, TPX2, or both reduced the invasion and migration ability of CRC cells while inhibiting epithelial-mesenchymal transition. Co-knockdown of AURKA and TPX2 enhanced the inhibition of CRC cells. Combined knockdown was more effective in suppressing the malignant phenotype in CRC, providing ideas and basic data for CRC treatment. |
| Publish Date |
2024-12-27 13:37 |
| Citation |
Sheng GX, Zhang YJ, Shang T. Synergistic inhibition of colorectal cancer progression by silencing Aurora A and the targeting protein for Xklp2. World J Gastrointest Surg 2025; 17(1): 97148
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| URL |
https://www.wjgnet.com/1948-9366/full/v17/i1/97148.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i1.97148 |
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