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Articles Published Processes
8/27/2024 3:11:20 PM | Browse: 68 | Download: 220
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Received |
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2024-06-05 11:17 |
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Peer-Review Started |
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2024-06-05 11:17 |
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To Make the First Decision |
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Return for Revision |
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2024-07-05 02:54 |
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Revised |
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2024-07-17 14:01 |
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Second Decision |
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2024-08-02 05:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-08-12 09:37 |
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Articles in Press |
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2024-08-12 09:37 |
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Publication Fee Transferred |
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2024-08-14 07:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-08-20 06:21 |
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Publish the Manuscript Online |
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2024-08-27 15:11 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Dexmedetomidine ameliorates diabetic intestinal injury by promoting the polarization of M2 macrophages through the MMP23B pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Man Lu, Xiao-Wen Guo, Fang-Fang Zhang, Dan-Hong Wu, Di Xie and Feng-Qin Luo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Feng-Qin Luo, MD, Attending Doctor, Doctor, Doctor, Department of Anesthesiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Lane, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. 3021702500@qq.com |
| Key Words |
Diabetes; Dexmedetomidine; Intestinal barrier; Piezo1; Tight junctions |
| Core Tip |
This study investigates the protective role of dexmedetomidine (DEX) in diabetic intestinal injury through the MMP23B pathway. The findings reveal that DEX acts as a sedative and enhances intestinal barrier function by promoting M2 macrophage polarization and reducing mitochondrial dysfunction. Streptozotocin-induced diabetic mice and Caco-2 cell models provide robust evidence of the potential therapeutic benefits of DEX, offering insights into its dual functionality in managing sedation and intestinal healing under diabetic conditions. This research can pave the way for the development of new treatment strategies targeting intestinal complications in diabetic patients. |
| Publish Date |
2024-08-27 15:11 |
| Citation |
<p>Lu M, Guo XW, Zhang FF, Wu DH, Xie D, Luo FQ. Dexmedetomidine ameliorates diabetic intestinal injury by promoting the polarization of M2 macrophages through the MMP23B pathway. <i>World J Diabetes</i> 2024; 15(9): 1962-1978</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i9/1962.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i9.1962 |
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