Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	97198
Country	China

Received	2024-05-25 11:05
Peer-Review Started	2024-05-25 11:07
To Make the First Decision
Return for Revision	2024-06-19 06:37
Revised	2024-06-29 04:04
Second Decision	2024-07-26 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-26 08:41
Articles in Press	2024-07-26 08:41
Publication Fee Transferred	2024-08-07 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-13 04:45
Publish the Manuscript Online	2024-09-09 08:41

ISSN	1948-5204 (online)
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Category	Biology
Manuscript Type	Basic Study
Article Title	Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Zu-Gui Tang, Tie-Mei Chen, Yi Lu, Zhe Wang, Xi-Cheng Wang and Yi Kong
ORCID	Author(s) ORCID Number Zu-Gui Tang http://orcid.org/0009-0009-0762-2447 Tie-Mei Chen http://orcid.org/0009-0005-4687-4226 Yi Lu http://orcid.org/0009-0005-5886-5677 Zhe Wang http://orcid.org/0000-0003-4220-5103 Xi-Cheng Wang http://orcid.org/0000-0002-8747-1387 Yi Kong http://orcid.org/0000-0001-8205-339X
Funding Agency and Grant Number	Funding Agency Grant Number Guangdong Basic and Applied Basic Research Foundation 2019A1515011609 Project of Educational Commission of Guangdong Province of China 2018KQNCX124 Guangzhou Science and Technology Key Point Project 202103000041
Corresponding Author	Yi Kong, PhD, Associate Professor, Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, No. 1068 Xueyuan Avenue, Nanshan District, Shenzhen 518000, Guangdong Province, China. yi.kong@siat.ac.cn
Key Words	Mesenchymal stem cells; Exosomes; Extracellular vesicles; Gemcitabine; Pancreatic cancer; Drug delivery
Core Tip	This study investigates the utilization of exosomes derived from human bone marrow mesenchymal stem cells as a novel system to deliver gemcitabine (GEM) for the treatment of pancreatic cancer. Through the optimization of GEM loading into exosomes, the results indicate that exosomes loaded with GEM (Exo-GEM) have a potent cytotoxicity against pancreatic cancer cells by enhancing their apoptosis in vitro. These findings underscore the potential of Exo-GEM as a more efficient and targeted therapeutic approach for enhancing therapeutic efficacy in patients with pancreatic cancer.
Publish Date	2024-09-09 08:41
Citation	<p>Tang ZG, Chen TM, Lu Y, Wang Z, Wang XC, Kong Y. Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis. <i>World J Gastrointest Oncol</i> 2024; 16(9): 4006-4013</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i9/4006.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i9.4006

Full Article (PDF)	WJGO-16-4006-with-cover.pdf
Manuscript File	97198_Auto_Edited_061443.docx
Answering Reviewers	97198-answering-reviewers.pdf
Audio Core Tip	97198-audio.mp3
Biostatistics Review Certificate	97198-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97198-conflict-of-interest-statement.pdf
Copyright License Agreement	97198-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97198-foundation-statement.pdf
Institutional Review Board Approval Form or Document	97198-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	97198-non-native-speakers.pdf
Peer-review Report	97198-peer-reviews.pdf
Scientific Misconduct Check	97198-scientific-misconduct-check.png
Scientific Editor Work List	97198-scientific-editor-work-list.pdf
CrossCheck Report	97198-crosscheck-report.pdf