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Articles Published Processes
9/9/2024 8:41:19 AM | Browse: 237 | Download: 808
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Received |
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2024-05-25 11:05 |
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Peer-Review Started |
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2024-05-25 11:07 |
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First Decision by Editorial Office Director |
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2024-06-19 05:07 |
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Return for Revision |
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2024-06-19 06:37 |
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Revised |
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2024-06-29 04:04 |
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Publication Fee Transferred |
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2024-08-07 09:16 |
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Second Decision by Editor |
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2024-07-26 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-07-26 08:41 |
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Articles in Press |
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2024-07-26 08:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-08-13 04:45 |
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Publish the Manuscript Online |
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2024-09-09 08:41 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zu-Gui Tang, Tie-Mei Chen, Yi Lu, Zhe Wang, Xi-Cheng Wang and Yi Kong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Basic and Applied Basic Research Foundation |
2019A1515011609 |
| Project of Educational Commission of Guangdong Province of China |
2018KQNCX124 |
| Guangzhou Science and Technology Key Point Project |
202103000041 |
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| Corresponding Author |
Yi Kong, PhD, Associate Professor, Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, No. 1068 Xueyuan Avenue, Nanshan District, Shenzhen 518000, Guangdong Province, China. yi.kong@siat.ac.cn |
| Key Words |
Mesenchymal stem cells; Exosomes; Extracellular vesicles; Gemcitabine; Pancreatic cancer; Drug delivery |
| Core Tip |
This study investigates the utilization of exosomes derived from human bone marrow mesenchymal stem cells as a novel system to deliver gemcitabine (GEM) for the treatment of pancreatic cancer. Through the optimization of GEM loading into exosomes, the results indicate that exosomes loaded with GEM (Exo-GEM) have a potent cytotoxicity against pancreatic cancer cells by enhancing their apoptosis in vitro. These findings underscore the potential of Exo-GEM as a more efficient and targeted therapeutic approach for enhancing therapeutic efficacy in patients with pancreatic cancer. |
| Publish Date |
2024-09-09 08:41 |
| Citation |
Tang ZG, Chen TM, Lu Y, Wang Z, Wang XC, Kong Y. Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis. World J Gastrointest Oncol 2024; 16(9): 4006-4013 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i9/4006.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i9.4006 |
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