Publication Name	World Journal of Gastroenterology
Manuscript ID	9724
Country	Italy

Received	2014-02-25 20:48
Peer-Review Started	2014-02-26 09:01
To Make the First Decision	2014-03-27 20:58
Return for Revision	2014-03-31 10:22
Revised	2014-06-04 00:00
Second Decision	2014-07-11 17:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:17
Articles in Press	2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-12 15:55
Typeset the Manuscript	2014-11-17 15:34
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gut microbiota in alcoholic liver disease: Pathogenetic role and therapeutic perspectives
Manuscript Source	Unsolicited Manuscript
All Author List	Giulia Malaguarnera, Maria Giordano, Giuseppe Nunnari, Gaetano Bertino and Michele Malaguarnera
Funding Agency and Grant Number
Corresponding Author	Maria Giordano, MD, Research Centre “The Great Senescence”, University of Catania, Cannizzaro Hospital, 829 Via Messina, 95100 Catania, Italy. maria-gior@hotmail.it
Key Words	Alcoholic liver disease; Bacterial translocation; Dysbiosis; Prebiotics; Probiotics; Synbiotic; Gut microbiota; Endotoxin
Core Tip	A close anatomical and functional relationship between gut and liver exists. Blood circulated in the portal vein transfers various toxic compounds for filtration by liver. Endotoxin is a lipopolysaccharide derived from the cell wall of Gram negative bacteria presents in the intestine, which is absorbed from intestinal epithelium and transported to the liver and Kupffer cells through the portal vein. A qualitative (dysbiosis) and quantitative (bacterial overgrowth) alteration of intestinal microbiome are the causes of an increase of endotoxins and subsequently, liver damage. The new treatments try to contrast dysbiosis and bacterial overgrowth decreasing evolution of alcohol liver disease.
Publish Date	2014-12-02 10:46
Citation	Malaguarnera G, Giordano M, Nunnari G, Bertino G, Malaguarnera M. Gut microbiota in alcoholic liver disease: Pathogenetic role and therapeutic perspectives. World J Gastroenterol 2014; 20(44): 16639-16648
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16639.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16639

Full Article (PDF)	WJG-20-16639.pdf
Full Article (Word)	WJG-20-16639.doc
Manuscript File	9724-Review.doc
Answering Reviewers	9724-Answering reviewers.pdf
Copyright License Agreement	9724-Copyright Assignment.pdf
Peer-review Report	9724-Peer reviews.pdf
Scientific Misconduct Check	9724-CrossCheck.jpg
Scientific Editor Work List	9724-Scientific editor work list.pdf