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Articles Published Processes
8/29/2024 8:28:54 AM | Browse: 112 | Download: 593
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Received |
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2024-05-27 03:03 |
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Peer-Review Started |
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2024-05-27 03:03 |
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First Decision by Editorial Office Director |
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2024-07-19 02:28 |
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Return for Revision |
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2024-07-21 04:32 |
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Revised |
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2024-07-29 08:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-08-12 05:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-08-12 09:41 |
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Articles in Press |
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2024-08-12 09:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-08-22 01:25 |
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Publish the Manuscript Online |
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2024-08-29 08:28 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
Immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Qiong Xie, Chun-Chun Li, Mei-Rong Yu and Jiang Cao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Natural Science Foundation of China |
No. LTGC23H200005 |
| Medical Science and Technology Project of Zhejiang Province |
No. 2022RC167 |
| Zhejiang Provincial Natural Science Foundation of China |
No. LQ19H160017 |
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| Corresponding Author |
Jiang Cao, PhD, Professor, Center for Basic and Translational Research, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, China. caoj@zju.edu.cn |
| Key Words |
Gastric signet-ring cell carcinoma; Single-cell RNA sequencing; Immunosuppressive tumor microenvironment; Immune checkpoint blockade therapy; Prognosis |
| Core Tip |
Two single-cell RNA sequencing studies in 2023 revealed an immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma (GSRCC). Advanced GSRCC was enriched for immunosuppressive factors, including the loss of CXCL13+-cluster of differentiation 8+-Tex cells and declined clonal crosstalk among populations of T and B cells. In addition, GSRCC was mainly infiltrated by follicular B cells. Distinct molecular characteristics and more effective immunotherapy strategies should be investigated to improve the clinical outcomes of GSRCC. |
| Publish Date |
2024-08-29 08:28 |
| Citation |
Xie YQ, Li CC, Yu MR, Cao J. Immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma. World J Clin Oncol 2024; 15(9): 1126-1131 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i9/1126.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i9.1126 |
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