| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the PI3K/AKT signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sheng-Xi Xiong, Lin-Juan Huang, Han-Shuang Liu, Xiao-Xiao Zhang, Min Li, Yu-Bing Cui, Chen Shao and Xiao-Lei Hu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Anhui Province |
No. 2208085MH216 |
| Major Natural Science and Technology Project of Bengbu Medical College |
No. 2020byfy004 |
| Scientific Research Program of Anhui Provincial Health Commission |
No. AHWJ2023BAc10028 |
|
| Corresponding Author |
Xiao-Lei Hu, PhD, Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. caesar80@163.com |
| Key Words |
Dagliflozin; Macrophage polarization; Inflammation; Macrophage apoptosis; Phosphoinositide 3-kinase/protein kinase B signaling pathway |
| Core Tip |
Sodium–glucose cotransporter (SGLT)-2 inhibitors, a new type of hypoglycemic drug, are widely used in clinical practice. However, their specific protective mechanism in diabetic kidneys has not been fully elucidated. We induced macrophage polarization and apoptosis in a mouse model of type 2 diabetes mellitus in vitro and treated it with dapagliflozin. Ultimately, our study revealed that dapagliflozin attenuates macrophage M1 polarization and apoptosis, reduces inflammatory responses, thereby protecting the kidney, and is associated with the inhibition of the PI3K/AKT signaling pathway. |
| Publish Date |
2024-12-30 09:47 |
| Citation |
Xiong SX, Huang LJ, Liu HS, Zhang XX, Li M, Cui YB, Shao C, Hu XL. Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the PI3K/AKT signaling pathway. World J Diabetes 2025; 16(2): 97287 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i2/97287.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i2.97287 |
