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Articles Published Processes
12/11/2024 10:19:42 AM | Browse: 78 | Download: 528
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Received |
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2024-05-27 15:55 |
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Peer-Review Started |
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2024-05-27 15:55 |
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First Decision by Editorial Office Director |
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2024-09-17 02:59 |
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Return for Revision |
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2024-09-17 02:59 |
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Revised |
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2024-09-26 12:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-11-19 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-19 09:04 |
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Articles in Press |
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2024-11-19 09:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-11-28 08:52 |
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Publish the Manuscript Online |
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2024-12-11 10:19 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu-Fan Zhang, Qian Chen, Qin Jiang and Qiong-Ying Hu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qiong-Ying Hu, MD, PhD, Associate Professor, Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Jinniu District, Chengdu 610072, Sichuan Province, China. qiongyinghu@163.com |
| Key Words |
SH-4-54; Colorectal cancer; Cancer stem-like cells; Stemness; Chemosensitivity |
| Core Tip |
Targeting cancer stem cells (CSCs) has emerged as an appealing approach for combating colorectal cancer (CRC) and improving treatment outcomes. Specifically, the study employed a compound called SH-4-54, which targets the SH2 domain of both signal transducer and activator of transcription (STAT)3 and STAT5, thereby exhibiting anticancer activity in colorectal CSCs. Taken together, our study suggests that SH-4-54 is a promising molecule that can target and inhibit colorectal CSCs by modulating the STAT3 signaling pathway, thereby presenting a potential therapeutic approach for combating CRC. |
| Publish Date |
2024-12-11 10:19 |
| Citation |
Zhang XF, Chen Q, Jiang Q, Hu QY. Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer. World J Clin Oncol 2025; 16(2): 97296 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i2/97296.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i2.97296 |
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